Effect of roasting on the formation of chlorogenic acid lactones in coffee.
- A. Farah, T. de Paulis, L. Trugo, Peter R. Martin
- Chemistry, MedicineJournal of Agricultural and Food Chemistry
- 10 February 2005
The levels of lactones in roasted coffee do not reflect the levels of precursors in green coffee, suggesting that roasting causes isomerization of chlorogenic acids prior to the formation of lactone levels.
Chlorogenic acids and lactones in regular and water-decaffeinated arabica coffees.
- A. Farah, T. de Paulis, D. P. Moreira, L. Trugo, Peter R. Martin
- Chemistry, MedicineJournal of Agricultural and Food Chemistry
- 25 January 2006
Differences in CGA and CGL contents of regular and decaffeinated roasted coffees appear to be relatively small, but they may be enough to affect flavor characteristics as well as the biopharmacological properties of the final beverage, suggesting the need for further study.
Interaction of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 with the Negative Allosteric Antagonist Site Is Required for Potentiation of Receptor Responses
- Yelin Chen, Y. Nong, P. Conn
- Biology, ChemistryMolecular Pharmacology
- 1 May 2007
Exciting advances have been made in the discovery of selective positive allosteric modulators of the metabotropic glutamate receptor (mGluR) mGluR5. These compounds may provide a novel approach that…
Biphenyl-indanone A, a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor Subtype 2, Has Antipsychotic- and Anxiolytic-Like Effects in Mice
Results indicate that BINA is a selective mGluR2 positive allosteric modulator and provide further support for the growing evidence that selective allosterics potentiators of mGLUR2 mimic many of the in vivo actions of m GluR 2/3 agonists that may predict therapeutic utility of these compounds.
Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4
- C. Niswender, Kari A. Johnson, P. Conn
- Biology, ChemistryMolecular Pharmacology
- 1 November 2008
High-throughput screening found more than 400 novel PAMs of mGluR4, and resolution of the regioisomers of the lead revealed that this compound is a mixed allosteric agonist/PAM of m GluR 4, providing continued support for mGLUR4 as a therapeutic target in PD.
High affinity dopamine D2 receptor radioligands. 1. Regional rat brain distribution of iodinated benzamides.
- R. Kessler, M. Ansari, M. Ebert
- Chemistry, BiologyJournal of Nuclear Medicine
- 1 August 1991
Five 125I-labeled substituted benzamides, which are close structural analogues of (S)-sulpiride, eticlopride, and isoremoxipride, were evaluated for their selective in vivo uptake into dopamine D2 receptor rich tissue of the rat brain and the observed uptake ratios correlated poorly with the affinity constants for the dopamine D1 receptor alone, but were highly correlated with the product of the receptor dissociation constant and the apparent lipophilicity.
Antioxidant effects of dihydrocaffeic acid in human EA.hy926 endothelial cells.
- Junjun Huang, T. de Paulis, J. M. May
- BiologyJournal of Nutritional Biochemistry
- 1 December 2004
Quinides of roasted coffee enhance insulin action in conscious rats.
- J. Shearer, A. Farah, D. Wasserman
- BiologyJournal of NutriLife
- 1 November 2003
It is demonstrated that DIFEQ increases whole-body glucose disposal independently of skeletal muscle Rg, and decaffeinated coffee extract or 3,4-diferuloyl-1,5-quinide did not affect heart rate, blood pressure, plasma nonesterified fatty acids or liver aminotransferase activity.
Dicinnamoylquinides in roasted coffee inhibit the human adenosine transporter.
- T. de Paulis, D. Schmidt, Peter R. Martin
- BiologyEuropean Journal of Pharmacology
- 10 May 2002
Evaluation of 5‐[18F]Fluoropropylepidepride as a potential pet radioligand for imaging dopamine D2 receptors
- R. Kessler, J. Votaw, M. Ebert
- Biology, ChemistrySynapse
- 1 November 1993
Although uptake in the striatum is reversible, an equilibrium between receptor bound [18F]5‐FPrEpid in striatum and [18f]5·fluoropropylepidepride in plasma is not reached within 5 h postinjection.
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