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Interaction between midazolam and clarithromycin: comparison with azithromycin.
It is concluded that a drug interaction exists between midazolam and clarithromycin which could be of clinical importance and no such effect is present with azithromyc. Expand
Influence of the antibiotics erythromycin and azithromycin on the pharmacokinetics and pharmacodynamics of midazolam.
Pharmacodynamic tests consistently showed significant differences after erythromycin pretreatment compared to control, but not after azithromycin, which causes clinically significant changes in the pharmacokinetics and pharmacodynamics of midazolam. Expand
Fluconazole: comparison of pharmacokinetics, therapy and in vitro susceptibility
The susceptibility of fungi to fluconazole in vitro and in vivo correlates well with the concentrations of the drug measured in various compartments of the body, which means that the dosage may need to be decreased in patients with renal impairment. Expand
Long term azithromycin therapy in cystic fibrosis patients: a study on drug levels and sputum properties.
The findings suggest that antipseudomonal activity has to be considered among the potential mechanisms of macrolide therapy in cystic fibrosis patients in vivo and viscoelasticity may be a valuable parameter in future clinical trials. Expand
Pharmacokinetic and pharmacodynamic interaction study between midazolam and the macrolide antibiotics, erythromycin, clarithromycin, and the azalide azithromycin.
It was concluded that coadministration of midazolam and azithromycin involves less clinical risk than with the 2 macrolides. Expand
Comparative pharmacokinetics of fluconazole and of itraconazole in Japanese and in German subjects.
In separate but identically designed studies the oral pharmacokinetics of 100 mg doses of the 2 antimycotics fluconazole and itraconazole were examined in Japanese and German subjects (both n = 12),Expand
Distribution of orally administered azithromycin in various blood compartments.
A significant reduction in bacterial viability was observed at subinhibitory extracellular concentrations of azithromycin as low as 0.03 mg/l, thus demonstrating antibacterial activity of the intracellularly enriched antibiotic. Expand
Comparative Tolerability of Intravenous Azithromycin, Clarithromycin and Erythromycin in Healthy Volunteers
The superior tolerability of azithromycin may avoid the discontinuation of intravenous antimicrobial therapy in seriously ill patients and assist in reducing the duration of hospitalisation and the cost of patient management. Expand
Influence of concomitant food intake on the oral absorption of two triazole antifungal agents, itraconazole and fluconazole
Itraconazole absorption was promoted by low stomach pH, long gastric retention time and a high fat content of the coadministered meal, whereas the pharmacokinetics of fluconazole was relatively insensitive to physiological changes in the gastrointestinal tract. Expand