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Identifying prodromal Parkinson's disease: pre-motor disorders in Parkinson's disease.
- R. Postuma, D. Aarsland, +4 authors T. Ziemssen
- Medicine, Psychology
- Movement disorders : official journal of the…
- 15 April 2012
Increasing recognition that Parkinson's disease (PD) may start outside of the substantia nigra has led to a rapidly expanding effort to define prodromal stages of PD, before motor signs permit… Expand
Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid
In multiple sclerosis, brain-reactive T cells invade the central nervous system (CNS) and induce a self-destructive inflammatory process. T-cell infiltrates are not only found within the parenchyma… Expand
Stroke-Induced Immunodepression: Experimental Evidence and Clinical Relevance
Stroke affects the normally well-balanced interplay of the 2 supersystems: the nervous and the immune system. Recent research elucidated some of the involved signals and mechanisms and, importantly,… Expand
Cardiovascular autonomic dysfunction in Parkinson's disease
Symptoms of cardiovascular dysautonomia are a common occurrence in Parkinson's disease (PD). In addition to this dysautonomia as part of PD itself, dysfunction of the autonomic nervous system (ANS)… Expand
Multiple sclerosis beyond EDSS: depression and fatigue
- T. Ziemssen
- Journal of the Neurological Sciences
- 1 February 2009
Depression and fatigue are common symptoms of multiple sclerosis and are the primary determinants of impaired quality of life in this demyelinating neurological disease. The twelve-month prevalence… Expand
Acute Cerebrovascular Disease in the Young: The Stroke in Young Fabry Patients Study
Background and Purpose— Strokes have especially devastating implications if they occur early in life; however, only limited information exists on the characteristics of acute cerebrovascular disease… Expand
Glatiramer acetate: mechanisms of action in multiple sclerosis.
Glatiramer acetate (GA), formerly known as copolymer 1, is a mixture of synthetic polypeptides composed of four amino acids resembling the myelin basic protein (MSP). GA has been shown to be highly… Expand
Optimizing treatment success in multiple sclerosis
Despite important advances in the treatment of multiple sclerosis (MS) over recent years, the introduction of several disease-modifying therapies (DMTs), the burden of progressive disability and… Expand
Therapeutic decisions in multiple sclerosis: moving beyond efficacy.
Several innovative disease-modifying treatments (DMTs) for relapsing-remitting multiple sclerosis have been licensed recently or are in late-stage development. The molecular targets of several of… Expand