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The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons.
Mutations in TDP-43 lead to familial ALS. Expanding evidence suggests that impaired mitochondrial dynamics likely contribute to the selective degeneration of motor neurons in SOD1-associated ALS. InExpand
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Mutation in Nuclear Pore Component NUP155 Leads to Atrial Fibrillation and Early Sudden Cardiac Death
Atrial fibrillation (AF) is the most common form of sustained clinical arrhythmia. We previously mapped an AF locus to chromosome 5p13 in an AF family with sudden death in early childhood. Here weExpand
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Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis
Spermatogenesis is a differentiation process during which diploid spermatogonial stem cells (SSCs) produce haploid spermatozoa. This highly specialized process is precisely controlled at theExpand
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Fine genetic and physical mapping of the CRb gene conferring resistance to clubroot disease in Brassica rapa
The use of clubroot resistance (CR) genes is an effective and economical approach for controlling Plasmodiophora brassicae, the causal agent of clubroot disease in Chinese cabbage (Brassica rapa) andExpand
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Di‐(2‐ethylhexyl) phthalate and bisphenol A exposure impairs mouse primordial follicle assembly in vitro
  • T. Zhang, L. Li, +7 authors W. Shen
  • Biology, Medicine
  • Environmental and molecular mutagenesis
  • 1 May 2014
Bisphenol‐A (BPA) and diethylhexyl phthalate (DEHP) are estrogenic compounds widely used in commercial plastic products. Previous studies have shown that exposure to such compounds have adverseExpand
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Proviral Insertion in Murine Lymphomas 2 (PIM2) Oncogene Phosphorylates Pyruvate Kinase M2 (PKM2) and Promotes Glycolysis in Cancer Cells*
Background: The protein-serine/threonine kinase PIM2 regulates glycolysis, but the mechanism is not fully elucidated. Results: PIM2 interacts with PKM2 and phosphorylates PKM2 on the Thr-454 residue.Expand
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Identification of a New Co-factor, MOG1, Required for the Full Function of Cardiac Sodium Channel Nav1.5*
  • L. Wu, S. Yong, +11 authors Q. Wang
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 14 March 2008
The cardiac sodium channel Nav1.5 is essential for the physiological function of the heart and contributes to lethal cardiac arrhythmias and sudden death when mutated. Here, we report that MOG1, aExpand
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Molecular epidemiology of hydropericardium syndrome outbreak-associated serotype 4 fowl adenovirus isolates in central China
In several parts of China, there have been a large number of hydropericardium syndrome (HPS) outbreaks caused by serotype 4 fowl adenovirus (FAdV­4) in broiler chickens since 2015. TheseExpand
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Jasmonate-mediated wound signalling promotes plant regeneration
Wounding is the first event triggering regeneration1–4. However, the molecular basis of wound signalling pathways in plant regeneration is largely unclear. We previously established a method to studyExpand
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Identification of Novel QTLs for Isolate-Specific Partial Resistance to Plasmodiophora brassicae in Brassica rapa
Plasmodiophora brassicae, the causal agent of clubroot disease of the Brassica crops, is widespread in the world. Quantitative trait loci (QTLs) for partial resistance to 4 different isolates of P.Expand
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