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Glucose promotes stress resistance in the fungal pathogen Candida albicans.
Metabolic adaptation, and in particular the modulation of carbon assimilatory pathways during disease progression, is thought to contribute to the pathogenicity of Candida albicans. Therefore, weExpand
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Effect of neuroactive compounds on the settlement of mussel (Perna canaliculus) larvae
article i nfo Herein, we present the first laboratory study on the effects of pharmacologically active compounds on larval settlement of the green-lipped mussel, Perna canaliculus. CompetentExpand
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Effects of Depleting the Essential Central Metabolic Enzyme Fructose-1,6-Bisphosphate Aldolase on the Growth and Viability of Candida albicans: Implications for Antifungal Drug Target Discovery
ABSTRACT The central metabolic enzyme fructose-1,6-bisphosphate aldolase (Fba1p) catalyzes a reversible reaction required for both glycolysis and gluconeogenesis. Fba1p is a potential antifungalExpand
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Regulatory effects of mussel (Aulacomya maoriana Iredale 1915) larval settlement by neuroactive compounds, amino acids and bacterial biofilms
Abstract Larval settlement responses of the ribbed mussel, Aulacomya maoriana Iredale 1915, were investigated after exposure to various chemicals and mono-species bacteria. Identification ofExpand
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Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension
Background: Pulmonary arterial hypertension (PAH) is a rare disease with an emerging genetic basis. Heterozygous mutations in the gene encoding the bone morphogenetic protein receptor type 2 (BMPR2)Expand
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Showcasing metabolomic applications in aquaculture: a review
Aquaculture production is currently challenged to meet the growing demands for seafood protein throughout the world. To achieve this growth in an efficient, safe and sustainable manner, novel toolsExpand
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Differential expression of novel metabolic and immunological biomarkers in oysters challenged with a virulent strain of OsHV‐1
&NA; Early lifestages of the Pacific oyster (Crassostrea gigas) are highly susceptible to infection by OsHV‐1 &mgr;Var, but little information exists regarding metabolic or pathophysiologicalExpand
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Metabolomic Strategies for Aquaculture Research: A Primer
Metabolomics is a fast-evolving field that provides qualitative and quantitative analyses of metabolites within cells, tissues or biofluids. Recent applications of metabolomics approaches inExpand
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Putative involvement of adrenergic receptors in regulation of mussel (Perna canaliculus) larval settlement
Abstract Settlement responses were investigated for mussel (Perna canaliculus) larvae after exposure to catecholamines and their precursor metabolites. Settlement and mortality assays were conductedExpand
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Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans
Background The genetic cause of primary immunodeficiency disease (PID) carries prognostic information. Objective We conducted a whole‐genome sequencing study assessing a large proportion of the NIHRExpand
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