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Calcium-induced alginate gelation was examined in terms of water content changes. The gelation was accompanied with considerable water loss, which reached about 50-60% (w/w) reduction in theExpand
Acid-Induced and Calcium-Induced Gelation of Alginic Acid : Bead Formation and pH-Dependent Swelling
The bead formation of alginic acid in the acidic medium (pH 1.0) was investigated in comparison with that of calcium-induced gel beads. The acid-induced gel beads could be visually observed in a fewExpand
Astrocytic contributions to blood-brain barrier (BBB) formation by endothelial cells: A possible use of aortic endothelial cell for In vitro BBB model
It is suggested that primary cultured BBECs, which had been primed by astrocytes in vivo, retain a higher sensitivity to astroCytes, and that even BAEC from extra-neural tissues, when cultured with astroicytes in close proximity in vitro, may acquire the similar phenotypes and serve for an extensive use of BBB model in vitro. Expand
[Cationic liposomes in gene delivery].
The role of liposomes is to condense DNA to form complexes with high affinity to cell surfaces where possible fusion or destabilization of the membrane and/or endocytosis are involved, but at present, little structure-activity relationships are known. Expand
Dissolution Phenomena of Organic Medicinals involving Simultaneous Phase Changes
A model was proposed to analyze the dissolution phenomena involving simultaneous phase changes and its experimental demonstration was done with p-hydroxybenzoic acid and phenobarbital which change toExpand
Interaction of Calcium-Induced Alginate Gel Beads with Propranolol
The loading capacity of calcium-induced alginate gel beads for propranolol, selected as a cationic model drug, was investigated with particular attention to the effects of excess Ca2+ in the beads,Expand
Properties of poly(lactic-co-glycolic acid) nanospheres containing protease inhibitors: camostat mesilate and nafamostat mesilate.
It was demonstrated that temperature-dependent drug release behavior was ascribable to the glass transition temperature of the polymer, which also affected the morphology of nanospheres upon dispersed in the release medium and influenced the drug release consequently. Expand
Coagulation recovery after warfarin‐induced hypoprothrombinaemia by oral administration of liposomally‐associated vitamin K1 to rabbits
The coagulation recovery time of the liposomal preparation was much faster than that of the other preparations and it was compared with the response to intravenous administration in which the vitamin was considered to be 100% available. Expand
Disulfide bond cleavage of human serum albumin and alterations of its secondary structure by cis-diamminedichloroplatinum(II)
Abstract cw -Diamminedichloroplatinum(II) ( cis -DDP) cleaved disulfide (S-S) bonds in human serum albumin (HSA) and brought about alterations of the secondary structure. The α-helix contentExpand
Synthesis of antibiotic-loaded hydroxyapatite beads and in vitro drug release testing.
To protect relatively unstable drugs from humidity and avoid contamination of drug-incorporated HAP beads an apparatus was designed with which the beads could be enclosed in vials in vacuo and under aseptic conditions on a bench-scale basis. Expand