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Accuracy of anti-ribosomal P protein antibody testing for the diagnosis of neuropsychiatric systemic lupus erythematosus: an international meta-analysis.
Anti-P antibody testing has limited diagnostic value for NPSLE, and it is not helpful in differentiating among various disease phenotypes. Expand
Potent Induction of IFN-α and Chemokines by Autoantibodies in the Cerebrospinal Fluid of Patients with Neuropsychiatric Lupus1
- D. Santer, T. Yoshio, S. Minota, T. Möller, K. Elkon
- The Journal of Immunology
- 15 January 2009
Findings are consistent with a two-step model of NPSLE whereby CSF autoantibodies bind to Ags released by neurocytotoxic Abs or other brain cell injury, and the resulting immune complexes stimulate IFN-α and proinflammatory cytokines and chemokines. Expand
Association of IgG anti-NR2 glutamate receptor antibodies in cerebrospinal fluid with neuropsychiatric systemic lupus erythematosus.
Blood-brain barrier damages and intrathecal synthesis of anti-N-methyl-D-aspartate receptor NR2 antibodies in diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus
These results demonstrate that the severity of BBB damages plays a crucial role in the development of ACS, the severest form of diffuse NPSLE, through the accelerated entry of larger amounts of anti-NR2 into the central nervous system. Expand
Influence of antibodies against infliximab and etanercept on the treatment effectiveness of these agents in Japanese patients with rheumatoid arthritis
It seems that the appearance of anti-infliximab antibodies might decrease infliximab serum concentrations and, thereby, reduce the agent’s effectiveness. Expand
IgG anti-NR2 glutamate receptor autoantibodies from patients with systemic lupus erythematosus activate endothelial cells.
- T. Yoshio, H. Okamoto, S. Hirohata, S. Minota
- Chemistry, Medicine
- Arthritis and rheumatism
- 1 February 2013
EC activation through the NF-κB signaling pathway induced by IgG anti-NR2 antibodies in the central nervous system of SLE patients may lead to inflammation of the blood-brain barrier, initiating the pathogenesis of neuropsychiatric SLE. Expand
Subarachnoid hemorrhage and systemic lupus erythematosus
The relatively common occurence of subarachnoid hemorrhage in SLE patients, and a significantly different clinical impact of SAH in respect to active and inactive SLE, were suggested from the results. Expand
Muscular polyarteritis nodosa as a cause of fever of undetermined origin: a case report and review of the literature
The term “muscular PAN” is proposed to increase awareness that muscle can be also a single-affected site as well as other well known sites such as appendix, gallbladder, uterus or testis, and skin. Expand
Local implantation of autologous mononuclear cells from bone marrow and peripheral blood for treatment of ischaemic digits in patients with connective tissue diseases.
Implantation of autologous MNCs from peripheral and bone marrow into the ischaemic digits was so effective in pain-relief and more clinical trials would be warranted to see whether this could be a new treatment modality for angiogenesis in connective tissue diseases as in Buerger's disease. Expand
Soluble fractalkine in the cerebrospinal fluid of patients with neuropsychiatric lupus.
- E. Sato, N. Iikuni, T. Yoshio, S. Minota, N. Kamatani, H. Okamoto
- Annals of the rheumatic diseases
- 1 September 2006
The role of soluble fractalkine (CX3CL1) is studied in NPSLE, a diagnosis under the American College of Rheumatology criteria for neuropsychiatric lupus syndromes, which implicates important roles for these chemokines in the pathogenesis of NPSSE. Expand