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Allelic imbalance and mutations of the PTEN gene in ovarian cancer
  • Misato Saito, A. Okamoto, +9 authors Tadao Tanaka
  • Biology, Medicine
  • International journal of cancer
  • 15 January 2000
The PTEN/MMAC1/TEP1 tumor‐suppressor gene, which maps to chromosome 10q23.3, is mutated and homozygously deleted in a variety of human tumors, including endometrioid‐type ovarian tumors. We examinedExpand
Allelic imbalance in chromosome band 18q21 and SMAD4 mutations in ovarian cancers
Recently, three candidate tumor suppressor genes, SMAD2 (MADR2/JV18–1), SMAD4 (DPC4), and DCC, were identified in chromosome band 18q21. We examined allelic imbalance (AI) in 18q21 using sixExpand
FGF7-like gene is associated with pericentric inversion of chromosome 9, and FGF7 is involved in the development of ovarian cancer.
Pericentric inversion of chromosome 9 is a common chromosomal aberration that may be involved in the pathogenesis of several types of cancer. Screening for structural balanced chromosomal aberrationsExpand