• Publications
  • Influence
Allelic imbalance and mutations of the PTEN gene in ovarian cancer
  • Misato Saito, A. Okamoto, +9 authors Tadao Tanaka
  • Biology, Medicine
  • International journal of cancer
  • 15 January 2000
The PTEN/MMAC1/TEP1 tumor‐suppressor gene, which maps to chromosome 10q23.3, is mutated and homozygously deleted in a variety of human tumors, including endometrioid‐type ovarian tumors. We examinedExpand
  • 88
  • 2
Allelic imbalance in chromosome band 18q21 and SMAD4 mutations in ovarian cancers
Recently, three candidate tumor suppressor genes, SMAD2 (MADR2/JV18–1), SMAD4 (DPC4), and DCC, were identified in chromosome band 18q21. We examined allelic imbalance (AI) in 18q21 using sixExpand
  • 32
  • 2
P53-dependent radiosensitizing effects of Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin on human oral squamous cell carcinoma cell lines.
Development of new molecular target therapeutic agents is expected to improve clinical outcome, ideally with efficacy in both single and combined treatment modalities. Because of the potential forExpand
  • 33
Hormonal regulation of synthesis and secretion of pS2 protein relevant to growth of human breast cancer cells (MCF-7).
We have recently identified human epidermal growth factor-like immunoreactive factor synthesized and secreted by human breast cancer cells (MCF-7) as a secretory protein encoded by the pS2 gene, theExpand
  • 47
  • PDF
Estrogen-inducible pS2 protein is not the key regulatory component in the proliferation of human breast cancer cells (MCF-7).
Exposure of human breast cancer cells (MCF-7) to tumor promoters such as 12-O-tetradecanoyl phorbol 13-acetate (TPA) for 24 h at concentrations of 1-100 nM resulted in marked inhibition of DNAExpand
  • 6
FGF7-like gene is associated with pericentric inversion of chromosome 9, and FGF7 is involved in the development of ovarian cancer.
Pericentric inversion of chromosome 9 is a common chromosomal aberration that may be involved in the pathogenesis of several types of cancer. Screening for structural balanced chromosomal aberrationsExpand
  • 23
Aberrant Synthesis and Secretion of a Human Epidermal Growth Factor-Like Immunoreactive Factor by Human Breast Cancer Cells
Previously we reported that human breast cancer cell strain MCF-7 released an extremely large amount of a human epidermal growth factor (hEGF)-like immunoreactive factor (designated as MCF-7 EGF)Expand
  • 3
Growth inhibition of human salivary gland tumor cells by introduction of progesterone (Pg) receptor and Pg treatment.
Cancer of the salivary gland is one of the common cancers in the head and the neck regions. This type of cancer develops in the minor and the major salivary glands, and it sometimes metastasizes toExpand
  • 10
  • PDF