Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
- W. Satake, Yuko Nakabayashi, T. Toda
- BiologyNature Genetics
- 1 December 2009
The results identify two new PD susceptibility loci, show involvement of autosomal dominant parkinsonism loci in typical PD and suggest that population differences contribute to genetic heterogeneity in PD.
A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2.
- S. Detera-Wadleigh, J. Badner, E. Gershon
- PsychologyProceedings of the National Academy of Sciences…
- 11 May 1999
By comprehensive screening of the entire genome, a genome-wide scan is conducted on approximately 396 individuals from 22 multiplex pedigrees by using 607 microsatellite markers to detect unreported loci for bipolar disorder, found support for proposed linkages, and gained evidence for the overlap of susceptibility regions for bipolar Disorder and schizophrenia.
Identification of multiple genetic loci linked to the propensity for "behavioral despair" in mice.
- T. Yoshikawa, A. Watanabe, Yuichi Ishitsuka, A. Nakaya, N. Nakatani
- Biology, PsychologyGenome Research
- 1 March 2002
The present quantitative trait study should open up avenues for identifying novel molecular targets for antidepressants and unraveling the complex genetic mechanisms of depressive and anxiety disorders.
DNA Methylation Status of SOX10 Correlates with Its Downregulation and Oligodendrocyte Dysfunction in Schizophrenia
- K. Iwamoto, M. Bundo, Tadafumi Kato
- Medicine, BiologyJournal of Neuroscience
- 1 June 2005
It is found that the cytosine-guanine dinucleotide (CpG) island of sex-determining region Y-box containing gene 10 (SOX10), an oligodendrocyte-specific transcription factor, tended to be highly methylated in brains of patients with schizophrenia, correlated with reduced expression of SOX10.
Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia
- Kazuo Yamada, D. Gerber, T. Yoshikawa
- Psychology, MedicineProceedings of the National Academy of Sciences
- 20 February 2007
The previous genetic association of altered calcineurin signaling with schizophrenia pathogenesis is supported and EGR3 is identified as a compelling susceptibility gene.
Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.
- R. Segurado, S. Detera-Wadleigh, N. Akarsu
- PsychologyAmerican Journal of Human Genetics
- 1 July 2003
The present results for the very narrow model are promising but suggest that more and larger data sets are needed to support linkage, as well as suggest that linkage might be detected in certain populations or subsets of pedigrees.
18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease
- R. Harada, N. Okamura, Y. Kudo
- Biology, MedicineJournal of Nuclear Medicine
- 1 February 2016
A novel tau PET tracer is developed through compound optimization of arylquinoline derivatives that bound to neurofibrillary tangles selectively and with a higher signal-to-background ratio than did THK5117 in Alzheimer disease patients.
Genome-Wide Association Study of Schizophrenia in Japanese Population
- Kazuo Yamada, Y. Iwayama, T. Yoshikawa
- Psychology, MedicinePLoS ONE
- 6 June 2011
A three-stage analysis of three independent cohorts consisting of a total of 2,535 samples from Japanese and Chinese populations for searching schizophrenia susceptibility genes using a GWAS approach finds the current data in Asian population would be helpful for deciphering ethnic diversity of schizophrenia etiology.
Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures.
- Naoko Tomioka, H. Yasuda, J. Aruga
- Biology, PsychologyNature Communications
- 22 July 2014
It is shown that a transinteraction of Elfn1 and mGluR7 controls targeted interneuron synapse development and that loss ofElfn1 results in hyperactivity and sensory-triggered epileptic seizures in mice, which define a common basis bridging neurological disorders.
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