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Urinary 2,5-Dichlorophenol as Biological Index for p-Dichlorobenzene Exposure in the General Population
The relationship between exposure to p-dichlorobenzene (p-DCB) and urinary excretion of 2,5-dichlorophenol (2,5-DCP), the major metabolite of p-DCB, was examined to evaluate the usefulness of theExpand
Determination of reduced and oxidized glutathione in erythrocytes by high-performance liquid chromatography with ultraviolet absorbance detection.
  • T. Yoshida
  • Chemistry, Medicine
  • Journal of chromatography. B, Biomedical…
  • 12 April 1996
TLDR
A method is described for simultaneous quantitation of reduced (GSH) and oxidized (GSSG) glutathione in erythrocytes by HPLC and the present method appears to be satisfactory for determination of these physiological concentrations in ERY Throatcytes. Expand
Identification of urinary metabolites of human subjects acutely poisoned by p-chloronitrobenzene.
TLDR
N-Acetylated metabolites of p-chloroaniline and 2-amino-5-chlorophenol, resulting from p-CNB by metabolism, were found in only one of eight individuals indicating that this pathway is weak or may be absent in some humans. Expand
Pharmacokinetic study of p-chloronitrobenzene in humans suffering from acute poisoning.
TLDR
The pharmacokinetics of p-chloronitrobenzene in human subjects suffering from acute poisoning was studied from the urinary excreted amount of each metabolite to the total amount of the five metabolites using a one-compartment model. Expand
Estimation of Absorption of Trihalomethanes and Carbon Tetrachloride in Low-Level Exposure by Inhalation Pharmacokinetic Analysis in Rats
TLDR
The authors' findings revealed differences in the absorption amounts among the substances for the same exposure concentrations, and extrapolation showed that more chloroform was absorbed by the rats than chlorodibromomethane, bromodichlorometHane, and carbon tetrachloride. Expand
Pharmacokinetic study of p-chloronitrobenzene in rat.
  • T. Yoshida
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 March 1994
TLDR
Urinary excretion was considered to be the most important pathway for disappearance of p-CNB, and N-Acetyl-S-(4-nitrophenyl)-L-cysteine was the most abundant urinary metabolite of p -CNB and comprised ca.1/2 of the total amount of the five metabolites excreted into the urine. Expand
Effect of alkyl chain on the uptake, distribution, and excretion of 35S-labeled alkyl sulfates in carp.
TLDR
Investigation of 35S-labeled alkyl sulfates of three different carbon numbers and carp found the radioactivity was found to be easily taken up into the fish body and distributed throughout the tissues and organs for any surfactant, but the concentration factors differed characteristically depending upon the number of carbons. Expand
Determination of p-chloronitrobenzene and its metabolites in urine by reversed-phase high-performance liquid chromatography.
  • T. Yoshida
  • Chemistry, Medicine
  • Journal of chromatography
  • 5 March 1993
TLDR
A simple, accurate and precise isocratic reversed-phase high-performance liquid chromatographic method (HPLC) using ultraviolet detection was developed for the determination of p-chloronitrobenzene (p-CNB) and seven of its metabolites in rat urine and demonstrated good accuracy and precision in both intra- and inter-day assays. Expand
Bioconcentration of alcohol ethoxylates in carp (Cyprinus carpio).
TLDR
Three labeled nonionic surfactants were investigated in carp exposed to concentrations of 0.2-0.6 mg X liter-1 using whole-body autoradiography and the liquid scintillation counting method, finding 14C radioactivity was rapidly absorbed into the fish body and distributed in skin, nasal and oral cavities, gills, brain, hepatopancreas, kidney, gall bladder, and intestinal content at comparatively high concentrations. Expand
Toxic effects of linear alkylbenzene sulfonate on the tiger prawn, Penaeus monodon.
TLDR
The toxic effects of linear alkybenzene sulfonate (LAS) on the larvae and juveniles of tiger prawn Penaeus monodon were tested and the hepatopancreatic glutathione (GSH) in juvenile tigers prawn was obviously depleted when LAS concentration was over 1.0 ppm. Expand
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