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Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
TLDR
The cloning of complementary DNAs encoding adiponectin receptors 1 and 2 by expression cloning supports the conclusion that they serve as receptors for globular and full-length adiponECTin, and that they mediate increased AMP kinase and PPAR-α ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectionin.
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A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.
TLDR
BLT2 provides a novel target for antiinflammatory therapy and promises to expand the knowledge of LTB(4) function, as the location of the gene suggests shared transcriptional regulation of these two receptors.
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The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo
TLDR
The purpose of this review is to highlight the molecular characterization of the ALX receptor and provide an overview of theALX-LXA4 axis responsible for anti-inflammatory and proresolving signals in vivo.
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A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
TLDR
The cloning of the complementary DNA encoding a cell-surface LTB4 receptor that is highly expressed in human leukocytes is reported, showing that L TB4 is a unique lipid mediator that interacts with both cell- surface and nuclear receptors.
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International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors
TLDR
The aim of this review is to provide the molecular evidence as well as the properties and significance of the leukotriene and lipoxin receptors, which has lead to the present nomenclature.
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Inhibitory Regulation of Rac Activation, Membrane Ruffling, and Cell Migration by the G Protein-Coupled Sphingosine-1-Phosphate Receptor EDG5 but Not EDG1 or EDG3
TLDR
The present results demonstrate that EDG5 is the first example of a hitherto-unrecognized type of receptors that negatively regulate Rac activity, thereby inhibiting cell migration and membrane ruffling.
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G2A Is a Proton-sensing G-protein-coupled Receptor Antagonized by Lysophosphatidylcholine*
TLDR
G2A is another proton-sensing GPCR, and LPC functions as an antagonist, not as an agonist, and regulates theProton-dependent activation of G2A.
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Hydroxyeicosanoids Bind to and Activate the Low Affinity Leukotriene B4 Receptor, BLT2*
TLDR
It is suggested that BLT2 functions as a low affinity receptor, with broader ligand specificity for various eicosanoids, and mediates distinct biological and pathophysiological roles from BLT1.
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The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury.
TLDR
Inhibition of leukotriene B4 suppressed leukocyte infiltration after injury, thereby attenuating the inflammatory reaction, sparing the white matter, and reducing neural apoptosis, as well as inducing better functional recovery.
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Two distinct leukotriene B4 receptors, BLT1 and BLT2.
  • T. Yokomizo
  • Biology, Medicine
    Journal of biochemistry
  • 1 February 2015
TLDR
An aspirin-dependent reduction in 12(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid was responsible for delayed skin wound healing, showing that the 12-HHT/BLT2 axis also plays an important role in skin biology.
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