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Acid sphingomyelinase inhibition suppresses lipopolysaccharide‐mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium‐induced
Lipopolysaccharide (LPS) and inflammatory cytokines cause activation of sphingomyelinases (SMases) and subsequent hydrolysis of sphingomyelin (SM) to produce a lipid messenger ceramide. The design ofExpand
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Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA, a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate
Lipopolysaccharide (LPS) and inflammatory cytokines cause activation of sphingomyelinases (SMases) and subsequent hydrolysis of sphingomyelin (SM) to produce a lipid messenger ceramide. The use ofExpand
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Fe3O4 nanoparticle-supported Cu(II)-β-cyclodextrin complex as a magnetically recoverable and reusable catalyst for the synthesis of symmetrical biaryls and 1,2,3-triazoles from aryl boronic acids
We report here on the preparation of an efficient, easily recoverable and reusable Fe3O4 magnetic nanoparticle-supported Cu(II)-β-cyclodextrin complex catalyst for the synthesis of symmetricalExpand
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CuSO4-Mediated Homocouplingof Arylboronic Acids under Ligand- and Base-Free Conditions in Air
The homocoupling of arylboronic acids mediated by very inexpensive and air stable copper(II) sulfate in N,N-dimethylformamide affords the corresponding symmetrical biaryls in moderate to good yields.Expand
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Lipase-catalyzed enantioselective acylation of prochiral 2-(ω-phosphono)alkyl-1,3-propanediols: Application to the enantioselective synthesis of ω-phosphono-α-amino acids
Abstract Lipase PS catalyzed acetylation of prochiral 2-(ω-phosphono)alkyl-1,3-propanediols 1a-c was found to proceed with high enantioselectivity. The applications of phosphonic chirons 2a-c thusExpand
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Synthesis and evaluation of a difluoromethylene analogue of sphingomyelin as an inhibitor of sphingomyelinase.
A sphingomyelin analogue 2, in which the long alkenyl chain and the phosphodiester moiety of sphingomyelin were replaced by a phenyl and an isosteric difluoromethylenephosphonic acid, was prepared toExpand
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Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP.
9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine (DFPP-DG) was designed as a multi-substrate analogue inhibitor against purine nucleoside phosphorylase (PNP) on the basis of X-rayExpand
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Synthesis of non-competitive inhibitors of sphingomyelinases with significant activity.
A series of short-chain analogues of N-palmitoylsphingosine-1-phosphate, modified by replacement of the phosphate and the long alkenyl side chain with hydrolytically stable difluoromethyleneExpand
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Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase
Ceramide is formed through sphingomyelin hydrolysis or de novo synthesis and may play a key role in cell growth, differentiation and apoptosis. To clarify which pathway tumor cells use to formExpand
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Synthesis of (alpha,alpha-Difluoroallyl)phosphonates from Alkenyl Halides or Acetylenes.
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