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Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
MicroRNAs (miRNAs) are a non-coding family of genes involved in post-transcriptional gene regulation. These transcripts are associated with cell proliferation, cell differentiation, cell death and… Expand
Geranylgeranylated Rho Small GTPase(s) Are Essential for the Degradation of p27Kip1 and Facilitate the Progression from G1 to S Phase in Growth-stimulated Rat FRTL-5 Cells*
- A. Hirai, S. Nakamura, +9 authors Y. Saitō
- Biology, Medicine
- The Journal of Biological Chemistry
- 3 January 1997
Cyclin-dependent kinase (Cdk) enzymes are activated for entry into the S phase of the cell cycle. Elimination of Cdk inhibitor protein p27Kip1 during the G1 to S phase is required for the activation… Expand
Prevalence and allele frequency estimation of bovine leukocyte adhesion deficiency (BLAD) in Holstein-Friesian cattle in Japan.
- H. Nagahata, T. Miura, +4 authors K. Nioka
- Biology, Medicine
- The Journal of veterinary medical science
- 1 April 1997
Blood samples from 796 Holstein dairy cows in 20 herds from 6 districts in Japan from June 1994 to August 1995 were examined to determine whether they were BLAD-free, BLAD carriers, or BLAD-affected… Expand
Geranylgeranyl-Pyrophosphate, an Isoprenoid of Mevalonate Cascade, Is a Critical Compound for Rat Primary Cultured Cortical Neurons to Protect the Cell Death Induced by 3-Hydroxy-3-Methylglutaryl-CoA…
We investigated the role of the intrinsic mevalonate cascade in the neuronal cell death (NCD) induced by the inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase in rat primary cortical… Expand
Circulating oxidized LDL forms complexes with beta2-glycoprotein I: implication as an atherogenic autoantigen.
- Kazuko Kobayashi, Makoto Kishi, +10 authors E. Matsuura
- Chemistry, Medicine
- Journal of lipid research
- 1 April 2003
Beta2-glycoprotein I (beta2-GPI) is a major antigen for antiphospholipid antibodies (Abs, aPL) present in patients with antiphospholipid syndrome (APS). We recently reported (J. Lipid Res., 42: 697,… Expand
Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface
- E. Matsuura, Y. Igarashi, T. Yasuda, D. Triplett, T. Koike
- The Journal of experimental medicine
- 1 February 1994
Anticardiolipin antibodies (aCL) derived from the sera of individuals exhibiting the antiphospholipid syndrome (APS) directly bind to beta 2- glycoprotein I (beta 2-GPI), which is adsorbed to an… Expand
Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor.
Anticardiolipin antibodies (aCL) found in sera from patients with SLE react with cardiolipin (CL) in the presence of a 50-kDa serum cofactor. The cofactor, which was identified to be beta… Expand
Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune…
A DNA vaccine constructed with the CMV promoter conjugated to env gp160 and rev genes has been shown to induce an effective Th1-type immune response when inoculated via an intramuscular route. In the… Expand
The stimulatory action of amphiphysin on dynamin function is dependent on lipid bilayer curvature
Amphiphysin is a major dynamin‐binding partner at the synapse; however, its function in fission is unclear. Incubation of large unilamellar liposomes with mice brain cytosol led to massive formation… Expand
Simvastatin induces the odontogenic differentiation of human dental pulp stem cells in vitro and in vivo.
Statin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, is known to promote bone formation. However, it is not clear whether statin affects the differentiation of pulp cells. This study… Expand