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Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations
BACKGROUND There is currently no objective practical guide to intensity of drug treatment for individuals with heart failure. We hypothesised that pharmacotherapy guided by plasma concentrations ofExpand
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Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin: new neurohormonal predictors of left ventricular function and prognosis after myocardial infarction.
BACKGROUND Newly discovered circulating peptides, N-terminal pro-brain natriuretic peptide (N-BNP) and adrenomedullin (ADM), were examined for prediction of cardiac function and prognosis andExpand
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Plasma brain natriuretic peptide in assessment of acute dyspnoea
Recognition of heart failure (HF) may be difficult in patients presenting with acute dyspnoea, particularly in the presence of chronic airways obstruction. Since increased secretion of the cardiacExpand
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Plasma amino-terminal pro-brain natriuretic peptide and accuracy of heart-failure diagnosis in primary care: a randomized, controlled trial.
OBJECTIVES The purpose of this study was to determine the effect of amino-terminal pro-brain natriuretic peptide (N-BNP) on the diagnostic accuracy of heart failure (HF) in primary care. BACKGROUNDExpand
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Immunoreactive amino‐terminal pro‐brain natriuretic peptide (NT‐PROBNP): a new marker of cardiac impairment
Human brain natriuretic peptide‐32 (BNP) (i.e. proBNP(77–108)), the mature form of BNP and secreted predominantly by the cardiac ventricle, is formed from a high molecular weight precursor,Expand
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Brain natriuretic peptide and n-terminal brain natriuretic peptide in the diagnosis of heart failure in patients with acute shortness of breath.
OBJECTIVES This study sought to compare the utility of measurement of plasma brain natriuretic peptide (BNP) and N-terminal brain natriuretic peptide (N-BNP) in the diagnosis of heart failure (HF) inExpand
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N-terminal pro-B-type natriuretic peptide-guided treatment for chronic heart failure: results from the BATTLESCARRED (NT-proBNP-Assisted Treatment To Lessen Serial Cardiac Readmissions and Death)
OBJECTIVES The purpose of this study was to compare the effects of N-terminal pro-B-type natriuretic peptide (NT-proBNP)-guided therapy with those of intensive clinical management and with usual careExpand
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Bioactivity and metabolism of C-type natriuretic peptide in normal man.
C-Type natriuretic peptide (CNP) is a recently identified member of the natriuretic peptide family with potent vasodepressor activity in experimental animals. Specific CNP receptors and geneExpand
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The amino-terminal portion of pro-brain natriuretic peptide (Pro-BNP) circulates in human plasma.
Using an antiserum raised in rabbits to a synthetic human brain natriuretic peptide (BNP) N-terminal fragment [ProBNP(1-13)], a single large molecular weight (MW) N-terminal form of ProBNP has beenExpand
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Effect of anticoagulants and storage temperatures on stability of plasma and serum hormones.
OBJECTIVES To determine the effect of different anticoagulants and storage conditions on the stability of hormones in plasma and serum. DESIGN AND METHODS Human blood samples were collected fromExpand
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