• Publications
  • Influence
HLF/HIF‐2α is a key factor in retinopathy of prematurity in association with erythropoietin
TLDR
Results from intraperitoneal injection of Epo into HLFkd/kd mouse suggest that Epo is one of the target genes of HLF responsible for experimental ROP, and Expression levels of various angiogenic factors revealed that only erythropoietin gene expression was significantly affected, in parallel with HLF expression. Expand
Abnormal Heart Development and Lung Remodeling in Mice Lacking the Hypoxia-Inducible Factor-Related Basic Helix-Loop-Helix PAS Protein NEPAS
TLDR
A novel regulatory mechanism is demonstrated in which the activities of Hif-1α and HIF-2α are negatively regulated by NEPAS in endothelial cells, which is pertinent to lung and heart development during the embryonic and neonatal stages. Expand
Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood.
TLDR
A novel method for isolating EPCs from UCB by a combination of negative immunoselection and cell culture techniques is reported and it is found that E PCs with low ALDH activity (Alde-Low) possess a greater ability to proliferate and migrate compared to those with high AL DH activity ( alde-High). Expand
The p53 Family Member Genes Are Involved in the Notch Signal Pathway*
TLDR
Findings show an association between the p53 family genes and Notch signaling and suggest a potential molecular mechanism for the involvement of the p 53family genes in normal development. Expand
Functional Analysis of Basic Transcription Element Binding Protein by Gene Targeting Technology
TLDR
Although general behavioral activities such as locomotion, rearing, and speed of movement were not so much affected in the BTEB−/− mutant mice, they showed clearly reduced activity levels in rotorod and contextual fear-conditioning tests; this finding was probably due to defective functions of the cerebellum, hippocampus, and amygdala. Expand
Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer.
TLDR
By affecting mitotic checkpoint function, CHFR inactivation likely plays a key role in tumorigenesis in gastric cancer, and the aberrant methylation of CHFR appears to be a good molecular marker with which to predict the sensitivity of gastric cancers to microtubule inhibitors. Expand
Umbilical cord blood-derived mesenchymal stem cells inhibit, but adipose tissue-derived mesenchymal stem cells promote, glioblastoma multiforme proliferation.
TLDR
The opposite effects of AT- MSCs and UCB-MSCs on GBM clearly demonstrate that differences must be considered when choosing a stem cell source for safety in clinical application, and suggest that AT-MSC may support GBM development in vivo by at least two distinct mechanisms-promoting angiogenesis and inhibiting apoptosis. Expand
Molecular Therapeutic Targets for Glioma Angiogenesis
TLDR
This review will focus on some topics related to molecular therapeutic targets for glioma angiogenesis, including VEGF, V EGF-induced proteins on endothelial cells, tissue factor, osteopontin, α v β 3 integrin, and thymidine phosphorylase. Expand
ΔNp63α functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes
TLDR
Findings support ΔNp63α as a master regulator of keratinocyte differentiation, and suggest a novel function of this protein in the maintenance of epithelial homeostasis. Expand
Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney.
TLDR
HIF-2alpha in the endothelium has a protective role against ischemia of the kidney via amelioration of oxidative stress through regulation of the antioxidative stress genes in cultured endothelial cells. Expand
...
1
2
3
4
5
...