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Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates
  • T. Yamashima
  • Biology, Medicine
  • Progress in Neurobiology
  • 31 October 2000
Although more than 8000 papers of apoptosis are published annually, there are very few reports concerning necrosis in the past few years. A number of recent studies using lower species animals haveExpand
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Possible Participation of Autocrine and Paracrine Vascular Endothelial Growth Factors in Hypoxia-induced Proliferation of Endothelial Cells and Pericytes (*)
Hypoxia is the principal factor that causes angiogenesis. These experiments were conducted to explore how it induces the proliferation of vascular cells, a key step in angiogenesis. Human umbilicalExpand
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[The Japanese version of RBANS (Repeatable Battery for the Assessment of Neuropsychological Status)].
In Japan, neuropsychological assessment of dementing illnesses has been done mainly using Mini-Mental State Examination (MMSE) and a revised version of Hasegawa Dementia Scale (HDS-R). However,Expand
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P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells.
The expression of a functional P-glycoprotein (P-gp) which pumps drugs out of brain capillary endothelial cells (BCEC) into blood was studied by evaluating the steady-state uptake and efflux ofExpand
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Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction
Age-dependent increase of peroxidation of membrane fatty acids such as arachidonic acid (ARA) and docosahexaenoic acid (DHA) in neurons was reported to cause a decline of the hippocampal long-termExpand
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Expression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicity.
A series of events initiated by glutamate-receptor interaction perturbs cellular homeostasis resulting in elevation of intracellular free calcium and cell death. Cells subject to such environmentalExpand
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Ca2+-dependent proteases in ischemic neuronal death: a conserved 'calpain-cathepsin cascade' from nematodes to primates.
From rodents to primates, transient global brain ischemia is a well known cause of delayed neuronal death of the vulnerable neurons including cornu Ammonis 1 (CA1) pyramidal cells of the hippocampus.Expand
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The role of lysosomal rupture in neuronal death
Apoptosis research in the past two decades has provided an enormous insight into its role in regulating cell death. However, apoptosis is only part of the story, and inhibition of neuronal necrosisExpand
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Proliferation of neural and neuronal progenitors after global brain ischemia in young adult macaque monkeys
To investigate the effect of global cerebral ischemia on brain cell proliferation in young adult macaques, we infused 5-bromo-2'-deoxyuridine (BrdU), a DNA replication indicator, into monkeysExpand
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Why do bridging veins rupture into the virtual subdural space?
  • T. Yamashima, R. Friede
  • Materials Science, Medicine
  • Journal of neurology, neurosurgery, and…
  • 1 February 1984
Electron microscopic data on human bridging veins show thin walls of variable thickness, circumferential arrangement of collagen fibres and a lack of outer reinforcement by arachnoid trabecules, allExpand
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