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Age-related changes in human D1 dopamine receptors measured by positron emission tomography

The effects of age on the binding parameters of11C-SCH23390, the highly selective ligand for central D1 dopamine receptors, at specific binding sites in the brain were studied and quantitative estimates of rate constants of association and dissociation were obtained.
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Computer-controlled large scale production of high specific activity [11C]RO 15-1788 for PET studies of benzodiazepine receptors.

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Visualization of specific binding sites of benzodiazepine in human brain.

The results indicated that Carbon-11 Ro15-1788 is a suitable radioligand for the study of benzodiazepine receptors in vivo in humans and associates and dissociates to specific and nonspecific binding sites rapidly and has a high ratio of specific receptor binding to nonspecial binding in vivo.
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Synthesis and evaluation of 11C-PK 11195 for in vivo study of peripheral-type benzodiazepine receptors using positron emission tomography.

The biodistribution of 3H-PK 11195, an antagonist of the peripheral-type benzodiazepine receptors, was studied in mice and radioactivity in the heart, lung, spleen, kidney and adrenal was significantly decreased by the coadministration of carrier PK 11 195, which indicated that PK 11195 specifically binds to the receptors.
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Alterations in biodistribution of [3H]Ro 15-1788 in mice by acute stress: possible changes in in vivo binding availability of brain benzodiazepine receptor.

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Preparation of 13N-β-phenethylamine☆

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Synthesis of 13N-labelled amines by reduction of 13N-labelled amides

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Preparation of 18F-labeled 6- and 2-fluoro-9-benzylpurine as a potential brain-scanning agent.

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Radioactive N,N‐Dimethylphenylethylamine: A Selective Radiotracer for In Vivo Measurement of Monoamine Oxidase‐B Activity in the Brain

Results indicate that DMPEA is a selective substrate for mouse brain MAO‐B both in vivo and in vitro and that the positron emitter [11C]DMPEA might be used instead of [14C]dMPEA as a radiotracer for in vivo measurement of MAO'B activity in human brain.
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Synthesis and evaluation of [11C]cyanoimipramine.

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