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Involvement of tumor necrosis factor-alpha in the pathogenesis of activated macrophage-mediated hepatitis in mice.
Involvement of tumor necrosis factor‐α in development of hepatic injury in galactosamine‐sensitized mice
Intravenous injection of lipopolysaccharide and D‐galactosamine, at doses of 0.2 μg/kg and 800 mg/kg, respectively, elicited massive hepatic necrosis within 24 hr in C3H/HeN mice. The plasma…
[Effects of E-3123, a new protease inhibitor, on several protease activities and on experimental acute pancreatitis].
- K. Miyamoto, I. Hishinuma, J. Nagakawa, N. Nagaoka, T. Yamanaka, T. Wakabayashi
- Biology, MedicineNihon yakurigaku zasshi. Folia pharmacologica…
- 1 May 1988
The results show that E-3123 may possess suppressing effects on pathogenesis and development of acute pancreatitis and in dogs with pancreatitis, increases in serum trypsin and lipase activities were significantly reduced by infusion of E- 3123.
Protective effects of (2E)-3-[5-(2,3-dimethoxy-6-methyl-1,4- benzoquinoyl)]-2-nonyl-2-propenoic acid on endotoxin-mediated hepatitis in mice.
- J. Nagakawa, I. Hishinuma, I. Yamatsu
- Chemistry, BiologyThe Journal of pharmacology and experimental…
- 1 July 1992
Oral pretreatment with E3330 attenuated the elevation of plasma tumor necrosis factor activity and protected mice from liver injury and inhibited the production of tumor Necrosis factor from cultured Propionibacterium acnes-elicited murine peritoneal macrophages on stimulation with lipopolysaccharide in vitro.
Protective effect of E3330, a novel quinone derivative, in galactosamine-induced hepatitis in rats.
- J. Nagakawa, K. Hirota, I. Yamatsu
- Biology, ChemistryThe Journal of pharmacology and experimental…
The results suggest that E3330 may exert its hepatoprotective effects through inhibition of an effect of endotoxin in galactosamine-induced hepatitis in rats.
Protective effects of E3330, a novel quinone derivative, on galactosamine/tumor necrosis factor-alpha-induced hepatitis in mice.
Suppressive effects of E3330, a novel quinone derivative, on tumor necrosis factor-α generation from monocytes and macrophages
Findings indicate that E3330 has a suppressive effect on TNF-α generation from monocytes/macrophages, regardless of origin or species, and this effect is based in part on the suppression of T NF-α mRNA expression.
Interleukin-Lα Enhances Hepatotoxicity of Tumor Necrosis Factor-α in Galactosamine-Sensitized Mice
It is suggested that TNF plays a major role in the pathogenesis of galactosamine/LPS hepatitis in mice and that IL-lα acts synergistically with TNF to enhance the hepatotoxic effect of recombinant murine TNF in galacto-sensitized mice.
A Novel Type of Retinoic Acid Receptor Antagonist: Synthesis and Structure‐Activity Relationships of Heterocyclic Ring‐Containing Benzoic Acid Derivatives.
[Pharmacological effects of butoxybenzyl hyoscyamine bromide on isolated smooth muscle organs].
- T. Wakabayashi, T. Yamanaka, Y. Kunii, T. Ogo
- Biology, ChemistryNihon yakurigaku zasshi. Folia pharmacologica…
- 1 March 1973
BHB showed relatively potent anti-BaCl2 action in the ileum and stomach, and Atr, PB and HBB were less potent than BHB in this regard.