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Improving the oral health of older people: the approach of the WHO Global Oral Health Programme.
The proportion of older people continues to grow worldwide, especially in developing countries. Non-communicable diseases are fast becoming the leading causes of disability and mortality, and inExpand
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Analgesic effect of intrathecally administered orexin‐A in the rat formalin test and in the rat hot plate test
Orexin‐A and orexin‐B (also known as hypocretin‐1 and hypocretin‐2) are hypothalamic peptides and regulate feeding behaviour, energy metabolism and the sleep‐wake cycle. Orexin‐A binds equally toExpand
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Urinary angiotensinogen as a marker of intrarenal angiotensin II activity associated with deterioration of renal function in patients with chronic kidney disease.
In chronic kidney disease (CKD), enhanced intrarenal angiotensin II (AngII) is involved in deterioration of renal function, but it is difficult to measure it. For assessment of the potential ofExpand
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Association Between Self-Reported Dental Health Status and Onset of Dementia: A 4-Year Prospective Cohort Study of Older Japanese Adults from the Aichi Gerontological Evaluation Study (AGES) Project
Objectives Studies have shown that people with cognitive impairment have poor dental health. However, the direction of causality remains unknown. This prospective cohort study aimed to determine theExpand
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Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists
&NA; This study evaluated the effects of spinally administered excitatory amino acid antagonists on the thermal hyperesthetic state induced by unilateral partial ligation of the sciatic nerve in theExpand
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Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.
Epoxyeicosatrienoic acids (EET) have antihypertensive and anti-inflammatory properties and play a role in the maintenance of renal vascular function. A novel approach to increase EET levels is toExpand
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Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice.
Overexpression of transforming growth factor beta (TGF-beta) has been shown to play pathogenic roles in progression of renal fibrosis, and the severity of tubulointerstitial fibrosis correlatesExpand
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Effects of intrathecally administered nociceptin, an opioid receptor-like1 (ORL1) receptor agonist, on the thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the
Nociceptin is a 17 amino acid peptide which acts as a potent endogenous agonist of the opioid receptor-like1 (ORL1) receptor. In the spinal cord, nociceptin is reported to depress glutamatergicExpand
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Effects of Azithromycin on Shiga Toxin Production by Escherichia coli and Subsequent Host Inflammatory Response
ABSTRACT Shiga toxin (Stx)-producing Escherichia coli (STEC) colonizes the human intestinal mucosa, produces Stx from phage, and causes the development of hemolytic-uremic syndrome via Stx-inducedExpand
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Angiotensin (1-7) Receptor Antagonism Equalizes Angiotensin II-Induced Hypertension in Male and Female Spontaneously Hypertensive Rats
Females are less sensitive to the hypertensive effects of angiotensin II compared with males, although the molecular mechanisms responsible are unknown. We hypothesize that differential activation ofExpand
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