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- Publications
- Influence
Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model
- R. Raedt, R. Clinckers, +10 authors A. Meurs
- Medicine
- Journal of neurochemistry
- 1 May 2011
J. Neurochem. (2011) 117, 461–469.
Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long‐term video‐EEG monitoring in the rat
- R. Raedt, A. Van Dycke, +6 authors P. Boon
- Medicine
- Acta neurologica Scandinavica
- 1 May 2009
Objective – Intrahippocampal injection of kainic acid (KA) in rats evokes a status epilepticus (SE) and leads to spontaneous seizures. However to date, precise electroencephalographic (EEG) and… Expand
Suppression of hippocampal epileptic seizures in the kainate rat by Poisson distributed stimulation
- T. Wyckhuys, P. Boon, R. Raedt, B. Van Nieuwenhuyse, K. Vonck, W. Wadman
- Medicine, Chemistry
- Epilepsia
- 1 November 2010
Purpose: Hippocampal deep brain stimulation (DBS) is an experimental therapy for patients with pharmacoresistant temporal lobe epilepsy (TLE). Despite the successful clinical application of DBS, the… Expand
Electrical stimulation for the treatment of epilepsy
- P. Boon, R. Raedt, V. D. Herdt, T. Wyckhuys, K. Vonck
- Medicine
- Neurotherapeutics
- 1 April 2009
SummaryDespite the advent of new pharmacological treatments and the high success rate of many surgical treatments for epilepsy, a substantial number of patients either do not become seizure-free or… Expand
High Frequency Deep Brain Stimulation in the Hippocampus Modifies Seizure Characteristics in Kindled Rats
- T. Wyckhuys, T. De Smedt, +8 authors P. Boon
- Psychology, Medicine
- Epilepsia
- 1 August 2007
Summary: Purpose: This experimental animal study evaluates the effect of high frequency deep brain stimulation (HFS DBS) on seizures in the Alternate Day Rapid Kindling model for temporal lobe… Expand
Comparison of hippocampal Deep Brain Stimulation with high (130Hz) and low frequency (5Hz) on afterdischarges in kindled rats
- T. Wyckhuys, R. Raedt, K. Vonck, W. Wadman, P. Boon
- Medicine
- Epilepsy Research
- 1 February 2010
Hippocampal Deep Brain Stimulation (DBS) is proposed as an experimental treatment for refractory epilepsy, but the optimal stimulation parameters are undetermined. High frequency hippocampal DBS at… Expand
Hippocampal deep brain stimulation induces decreased rCBF in the hippocampal formation of the rat
- T. Wyckhuys, S. Staelens, +6 authors P. Boon
- Medicine, Computer Science
- NeuroImage
- 1 August 2010
TLDR
Unconditioned adult-derived neurosphere cells mainly differentiate towards astrocytes upon transplantation in sclerotic rat hippocampus
- R. Raedt, A. V. Dycke, A. Waeytens, T. Wyckhuys, P. Boon
- Biology, Medicine
- Epilepsy Research
- 1 December 2009
PURPOSE
Cell transplantation is being investigated as an alternative treatment for medically refractory temporal lobe epilepsy (TLE). In this study the fate of adult-derived neurosphere cells was… Expand
Deep brain stimulation for epilepsy: knowledge gained from experimental animal models.
- T. Wyckhuys, P. Geerts, R. Raedt, K. Vonck, W. Wadman, P. Boon
- Medicine
- Acta neurologica Belgica
- 1 June 2009
Since the development of Deep Brain Stimulation (DBS) for Parkinson's Disease, DBS has been suggested as a treatment option for various other neurological disorders. Stimulation of deep brain… Expand