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STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death
Neurons lacking the calcium sensor STIM2 are protected from hypoxia-induced cell death. Resisting Ischemia Loss of blood flow to the brain—as can occur during a stroke—leads to the death of neurons,Expand
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STIM 2 Regulates Capacitive Ca 2 + Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death
htp:/ D ow nladed fom Excessive cytosolic calcium ion (Ca) accumulation during cerebral ischemia triggers neuronal cell death, but the underlying mechanisms are poorly understood. Capacitive Ca entryExpand
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Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach–brainstem axis
&NA; Gastric acid challenge of the rat and mouse stomach is signalled to the brainstem as revealed by expression of c‐Fos. The molecular sensors relevant to the detection of gastric mucosal acidosisExpand
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Endogenous neuropeptide Y depresses the afferent signaling of gastric acid challenge to the mouse brainstem via neuropeptide Y type Y2 and Y4 receptors
Vagal afferents signal gastric acid challenge to the nucleus tractus solitarii of the rat brainstem. This study investigated whether nucleus tractus solitarii neurons in the mouse also respond toExpand
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The COGITAT holeboard system as a valuable tool to assess learning, memory and activity in mice
The comprehensive and stress-free assessment of various aspects of learning and memory is a prerequisite to evaluate mouse models for neuropsychiatric disorders such as Alzheimer's disease orExpand
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Experimental gastritis in mice enhances anxiety in a gender-related manner
There is a gender-related comorbidity of pain-related and inflammatory bowel diseases with psychiatric diseases. Since the impact of experimental gastrointestinal inflammation on theExpand
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Multidrug-resistance gene 1-type p-glycoprotein (MDR1 p-gp) inhibition by tariquidar impacts on neuroendocrine and behavioral processing of stress
The multidrug-resistance gene 1-type p-glycoprotein (MDR1 p-gp) is a major gate-keeper at the blood-brain barrier (BBB), protecting the central nervous system from accumulation of toxic xenobioticsExpand
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Increase in gastric acid–induced afferent input to the brainstem in mice with gastritis
Acid challenge of the gastric mucosa is signaled to the brainstem. This study examined whether mild gastritis due to dextrane sulfate sodium (DSS) or iodoacetamide (IAA) enhances gastric acid-evokedExpand
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Selective increase of dark phase water intake in neuropeptide-Y Y2 and Y4 receptor knockout mice
Neuropeptide-Y (NPY) is involved in the regulation of ingestive behaviour and energy homeostasis. Since deletion of the NPY Y2 and Y4 receptor gene increases and decreases food intake, respectively,Expand
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