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Genomic analysis of the immune gene repertoire of amphioxus reveals extraordinary innate complexity and diversity.
It has been speculated that before vertebrates evolved somatic diversity-based adaptive immunity, the germline-encoded diversity of innate immunity may have been more developed. Amphioxus occupies… Expand
DNA methylation on N6-adenine in mammalian embryonic stem cells
It has been widely accepted that 5-methylcytosine is the only form of DNA methylation in mammalian genomes. Here we identify N6-methyladenine as another form of DNA modification in mouse embryonic… Expand
NPInter: the noncoding RNAs and protein related biomacromolecules interaction database
The noncoding RNAs and protein related biomacromolecules interaction database (NPInter; or ) is a database that documents experimentally determined functional interactions between noncoding RNAs… Expand
Inhibition of Breast Cancer Metastasis by Selective Synthetic Polypeptide against CXCR4
Metastasis shares many similarities with leukocyte trafficking. Among those chemokine receptors thought to be involved in hemopoietic cell homing, stromal cell-derived factor-1 and its receptor CXC… Expand
The developmental potential of iPSCs is greatly influenced by reprogramming factor selection.
Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they frequently exhibit high variation in… Expand
A Short-Form C-Type Lectin from Amphioxus Acts as a Direct Microbial Killing Protein via Interaction with Peptidoglycan and Glucan1
To investigate the evolution and immune function of C-type lectin in amphioxus, the primitive representative of the chordate phylum, we identified three C-type lectins consisting solely of a… Expand
Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing.
Telomere length homeostasis is essential for genomic stability and unlimited self-renewal of embryonic stem cells (ESCs). We show that telomere-associated protein Rif1 is required to maintain… Expand
N6-methyladenine DNA Modification in Glioblastoma
Genetic drivers of cancer can be dysregulated through epigenetic modifications of DNA. Although the critical role of DNA 5-methylcytosine (5mC) in the regulation of transcription is recognized, the… Expand
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA 4
Case-parent trios were used in a genome wide association study of cleft lip with/without cleft palate (CL/P). SNPs near two genes not previously associated with CL/P [MAFB: most significant SNP… Expand
Thymic Damage, Impaired Negative Selection, and Development of Chronic Graft-versus-Host Disease Caused by Donor CD4+ and CD8+ T Cells
Prevention of chronic graft-versus-host disease (cGVHD) remains a major challenge in allogeneic hematopoietic cell transplantation (HCT) owing to limited understanding of cGVHD pathogenesis and lack… Expand