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A gene atlas of the mouse and human protein-encoding transcriptomes.
The tissue-specific pattern of mRNA expression can indicate important clues about gene function. High-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on aExpand
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Large-scale analysis of the human and mouse transcriptomes
High-throughput gene expression profiling has become an important tool for investigating transcriptional activity in a variety of biological samples. To date, the vast majority of these experimentsExpand
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Melanopsin Is Required for Non-Image-Forming Photic Responses in Blind Mice
Although mice lacking rod and cone photoreceptors are blind, they retain many eye-mediated responses to light, possibly through photosensitive retinal ganglion cells. These cells express melanopsin,Expand
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Expression analysis of G Protein-Coupled Receptors in mouse macrophages
BackgroundMonocytes and macrophages express an extensive repertoire of G Protein-Coupled Receptors (GPCRs) that regulate inflammation and immunity. In this study we performed a systematic micro-arrayExpand
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c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation.
Precise control of hematopoietic stem cell (HSC) proliferation and differentiation is needed to maintain a lifetime supply of blood cells. Using genome-wide ENU mutagenesis and phenotypic screening,Expand
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Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin
Autosomal recessive limb-girdle muscular dystrophies (AR LGMDs) are a genetically heterogeneous group of disorders that affect mainly the proximal musculature. There are eight genetically distinctExpand
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Use of a Dense Single Nucleotide Polymorphism Map for In Silico Mapping in the Mouse
Rapid expansion of available data, both phenotypic and genotypic, for multiple strains of mice has enabled the development of new methods to interrogate the mouse genome for functional geneticExpand
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The Collaborative Cross, a community resource for the genetic analysis of complex traits
The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouseExpand
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Genetical Genomics: Spotlight on QTL Hotspots
Genetical genomics aims at identifying quantitative trait loci (QTLs) for molecular traits such as gene expression or protein levels (eQTL and pQTL, respectively). One of the central concepts inExpand
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Genetic Dissection of a Key Reproductive Barrier Between Nascent Species of House Mice
Reproductive isolation between species is often caused by deleterious interactions among loci in hybrids. Finding the genes involved in these incompatibilities provides insight into the mechanisms ofExpand
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