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- Publications
- Influence
Genetic studies of body mass index yield new insights for obesity biology
- A. Locke, Bratati Kahali, +479 authors E. K. Speliotes
- Biology, Medicine
- Nature
- 12 February 2015
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass… Expand
Discovery and Refinement of Loci Associated with Lipid Levels
- C. Willer, E. Schmidt, +256 authors G. Abecasis
- Medicine, Biology
- Nature Genetics
- 6 October 2013
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery… Expand
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- A. Morris, B. Voight, +201 authors M. McCarthy
- Biology, Medicine
- Nature Genetics
- 26 July 2012
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and… Expand
Defining the role of common variation in the genomic and biological architecture of adult human height
- A. Wood, T. Esko, +442 authors T. Frayling
- Biology, Medicine
- Nature Genetics
- 8 September 2014
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different… Expand
New genetic loci link adipose and insulin biology to body fat distribution
- D. Shungin, T. Winkler, +403 authors K. Mohlke
- Biology, Medicine
- Nature
- 16 December 2014
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body… Expand
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and…
- Leandra Ziad A Zargar Abdul Niveen M Benjamin Cecilia Robe Abarca-Gómez Abdeen Hamid Abu-Rmeileh Acosta-Cazar, Leandra Abarca-Gómez, +1,022 authors M. Ezzati
- Medicine
- The Lancet
- 16 December 2017
Summary Background Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide… Expand
Common variants associated with plasma triglycerides and risk for coronary artery disease
- Ron Do, C. Willer, +260 authors S. Kathiresan
- Biology, Medicine
- Nature Genetics
- 6 October 2013
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease… Expand
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
- B. Zhou, J. Bentham, +757 authors J. Cisneros
- Medicine
- The Lancet
- 7 January 2017
Summary Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood… Expand
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
- A. Mahajan, M. Go, +329 authors A. Morris
- Biology, Medicine
- Nature Genetics
- 9 February 2014
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and… Expand
Cohort profile: The Tromsø Study
- B. Jacobsen, A. E. Eggen, E. Mathiesen, T. Wilsgaard, I. Njølstad
- Medicine
- International journal of epidemiology
- 19 March 2011
The Tromso Study was initiated in 1974 in an attempt to help combat the high mortality of cardiovascular diseases in Norway, that was particularly pronounced among middle-aged men. In the mid-1970s,… Expand