Construction and Characterization of Listeria monocytogenes Mutants with In-Frame Deletions in the Response Regulator Genes Identified in the Genome Sequence
The mutant carrying a deletion in the ortholog of the Bacillus subtilis response regulator gene degU showed a clearly reduced virulence in mice, indicating that DegU is involved in the regulation of virulence-associated genes.
Response regulator DegU of Listeria monocytogenes regulates the expression of flagella-specific genes.
Epidemiology of Chagas disease in Europe: many calculations, little knowledge
- Jörn Strasen, T. Williams, G. Ertl, T. Zoller, A. Stich, O. Ritter
- MedicineClinical Research in Cardiology
An overview on the currently available data and calls for a German Chagas surveillance are given and there is a large variation in the estimated numbers on the incidence of ChagAs.
The cell envelope stress response mediated by the LiaFSRLm three-component system of Listeria monocytogenes is controlled via the phosphatase activity of the bifunctional histidine kinase LiaSLm.
- Frederike Fritsch, N. Mauder, T. Williams, J. Weiser, Markus Oberle, D. Beier
- 1 February 2011
Analysis of the LiaSR orthologue of Listeria monocytogenes shows that activation of LiaSR(Lm) results in a remodelling of the cell envelope via the massive upregulation of membrane-associated and extracytoplasmic proteins in the presence of inducing stimuli.
Conditional Overexpression of Neuronal Nitric Oxide Synthase Is Cardioprotective in Ischemia/Reperfusion
It is proposed that conditional transgenic overexpression of nNOS resulted in myocardial protection after ischemia/reperfusion injury because of inhibition of mitochondrial function and a reduction in reactive oxygen species generation.
Novel desmoplakin mutation: juvenile biventricular cardiomyopathy with left ventricular non-compaction and acantholytic palmoplantar keratoderma
Carvajal syndrome comprising severe early-onset heart failure with features of non-compaction cardiomyopathy, woolly hair and an acantholytic form of palmoplantar keratoderma in the authors' patient is caused.
Development and Characterization of an Inducible Rat Model of Chronic Thromboembolic Pulmonary Hypertension
A rat model is generated and standardized that not only resembles functional and histological features of CTEPH but also emulates thrombi fibrosis and permits preclinical testing of new pharmacological therapies againstCTEPH.
Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine…
Stimulation of IP3Rs with ET-1 induces Ca(2+ )release from the SR which is tunnelled to mitochondria via mitochondrial RyR leading to stimulation of mitochondrial ATP production.
Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy.
Nuclear calcineurin is a sensor for detecting Ca2+ release from the nuclear envelope via IP3R
The data provide an explanation how Ca2+ and calcineurin might regulate transcription in cardiomyocytes in response to neurohumoral signals independently from their role in cardiac contraction control.