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Fluorescent phallotoxin, a tool for the visualization of cellular actin.
A fluorescent derivative of phalloidin has been synthesized possessing high affinity to filamentous actin. This compound was used for visualization of actin-containing structures in eukaryoticExpand
Amatoxins, phallotoxins, phallolysin, and antamanide: the biologically active components of poisonous Amanita mushrooms.
This review gives a comprehensive account of the molecular toxicology of the bicyclic peptides obtained from the poisonous mushrooms of the genus Amanita, also including the most important analytical data. Expand
Virotoxins: actin-binding cyclic peptides of Amanita virosa mushrooms.
Virotoxins are toxic peptides singularly found in Amanita virosa mushrooms and the main component, viroisin, was selectively cleaved and submitted to Edman degradation, and was in part found to be the same as in phallotoxins. Expand
alpha-Amanitin uptake into hepatocytes. Identification of hepatic membrane transport systems used by amatoxins.
Hepatic uptake of amatoxins is mediated by the sinusoidal bile salt-transport systems which are also involved in the uptake of antamanide and phalloidin and supports the concept of a multispecificity of hepatic transport systems for a wide variety of amphipathic molecules. Expand
Interaction of actin with phalloidin: polymerization and stabilization of F-actin.
The cyclic peptide phalloidin, one of the toxic components of Amanita phalloides prevented the drop of viscosity of F-actin solutions after the addition of 0.6 M KI and inhibited the ATP splitting ofExpand
The phalloidin binding site of F‐actin.
Tritium‐containing affinity‐labelling derivatives of phalloidin, an alkylating iodoacetyl compound (EAL) and a photolabile, carbene generating diazirine (PAL), have been reacted with rabbit muscleExpand
The toxic peptides from Amanita mushrooms.
  • T. Wieland
  • Chemistry, Medicine
  • International journal of peptide and protein…
  • 12 January 2009
The results of 50 years of effort in the chemistry of Amanita toxins are reviewed, including conformations, chemical reactions and modification, syntheses and correlations between structures and biological activities. Expand
Interaction of phalloidin with actin.
Phalloidin, a toxic bicyclic peptide of rapid action from the toadstool, Amanita phalloides, gives rise to polymerization of G-actin to filamentous structures (Ph-actin) in a medium of low ionicExpand
Phallotoxins bind to actins
Comparative quantitative studies on binding of 3 Hand I4 C-labelled phallotoxins to Ph-actin obtained by polymerization of G-Actin in presence of the toxins and to Factin (which is transformed into a KI-resistant Phactin by the toxins). Expand