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The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism.
- H. Bergman, T. Wichmann, B. Karmon, M. Delong
- Psychology, Medicine
- Journal of neurophysiology
- 1 August 1994
1. The neuronal mechanisms underlying the major motor signs of Parkinson's disease were studied in the basal ganglia of parkinsonian monkeys. Three African green monkeys were systemically treated… Expand
Circuits and circuit disorders of the basal ganglia.
Views of the anatomy and function of the basal ganglia and their role in motor and nonmotor disorders have undergone major revisions during the past decades. The basal ganglia are now appreciated as… Expand
Reversal of experimental parkinsonism by lesions of the subthalamic nucleus.
Although it is known that Parkinson's disease results from a loss of dopaminergic neurons in the substantia nigra, the resulting alterations in activity in the basal ganglia responsible for… Expand
The primate subthalamic nucleus. I. Functional properties in intact animals.
1. The present study tests several key aspects of the current model of the intrinsic circuitry of the basal ganglia, in particular the degree to which basal ganglia-thalamocortical circuits are… Expand
Functional and pathophysiological models of the basal ganglia
Because of new data, anatomical and functional models of the basal ganglia in normal and pathological conditions (e.g. Parkinson's and Huntington's diseases) have recently come under greater… Expand
Neuronal firing before and after burst discharges in the monkey basal ganglia is predictably patterned in the normal state and altered in parkinsonism.
It is known that burst discharges in basal ganglia neurons are more common in parkinsonism than under normal conditions, but changes in the structure of burst or peri-burst epochs have not been… Expand
Pathophysiology of Parkinsonism
The motor signs of Parkinson's disease are thought to result in large part from a reduction of the level of dopamine in the basal ganglia. Over the last few years, many of the functional and… Expand
Comparison of MPTP-induced changes in spontaneous neuronal discharge in the internal pallidal segment and in the substantia nigra pars reticulata in primates
- T. Wichmann, H. Bergman, P. Starr, T. Subramanian, R. Watts, M. Delong
- Biology, Medicine
- Experimental Brain Research
- 1 April 1999
Abstract The basal ganglia are currently viewed as components of segregated corticosubcortical reentrant circuits. One of these circuits, the ”motor” circuit, is critically involved in the… Expand
Role of External Pallidal Segment in Primate Parkinsonism: Comparison of the Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinsonism and Lesions of the External Pallidal Segment
- Jesus Soares, M. A. Kliem, R. Betarbet, J. T. Greenamyre, B. Yamamoto, T. Wichmann
- Chemistry, Medicine
- The Journal of Neuroscience
- 21 July 2004
These experiments re-examined the notion that reduced activity in the external pallidal segment (GPe) results in the abnormalities of neuronal discharge in the subthalamic nucleus (STN) and the… Expand
The primate subthalamic nucleus. III. Changes in motor behavior and neuronal activity in the internal pallidum induced by subthalamic inactivation in the MPTP model of parkinsonism.
1. The effects of reversible and irreversible pharmacological manipulations of the neuronal activity in the subthalamic nucleus (STN) on parkinsonian motor signs and neuronal activity in the internal… Expand