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Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination
The transcriptional control of CNS myelin gene expression is poorly understood. Here we identify gene model 98, which we have named myelin gene regulatory factor (MRF), as a transcriptional regulatorExpand
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DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
The cell intrinsic factors that determine whether a neuron regenerates or undergoes apoptosis in response to axonal injury are not well defined. Here we show that the mixed-lineage dual leucineExpand
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NGF Controls Axonal Receptivity to Myelination by Schwann Cells or Oligodendrocytes
Axons dictate whether or not they will become myelinated in both the central and peripheral nervous systems by providing signals that direct the development of myelinating glia. Here we identify theExpand
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Distinct Stages of Myelination Regulated by γ-Secretase and Astrocytes in a Rapidly Myelinating CNS Coculture System
Mechanistic studies of CNS myelination have been hindered by the lack of a rapidly myelinating culture system. Here, we describe a versatile CNS coculture method that allows time-lapse microscopy andExpand
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JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
Neuronal injury induces JNK phosphorylation of DLK, which reduces DLK ubiquitination and creates a positive feedback loop to enhance JNK signaling and increase apoptosis.
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Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway.
Using a combination of local gene delivery and tolerizing DNA vaccination, we demonstrate that codelivery of the interleukin-4 (IL-4) gene and a DNA vaccine encoding the self-peptide proteolipidExpand
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ZFP191 is required by oligodendrocytes for CNS myelination.
The controlling factors that prompt mature oligodendrocytes to myelinate axons are largely undetermined. In this study, we used a forward genetics approach to identify a mutant mouse strainExpand
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Nerve Regeneration: Regrowth Stumped by Shared Receptor
Three different myelin proteins, Nogo, MAG, and OMgp, inhibit regenerating axons after CNS injury. New work reveals that they all share a common receptor and that blockade of this receptor promotesExpand
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Differential clustering of Caspr by oligodendrocytes and Schwann cells
Formation of the paranodal axoglial junction (PNJ) requires the presence of three cell adhesion molecules: the 155‐kDa isoform of neurofascin (NF155) on the glial membrane and a complex of Caspr andExpand
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Regulatory mechanisms of poly(ADP-ribose) polymerase
Here, we describe the latest developments on the mechanistic characterization of poly(ADP-ribose) polymerase (PARP) [EC 2.4.2.30], a DNA-dependent enzyme that catalyzes the synthesis of protein-boundExpand
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