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Congener-specific distribution of polychlorinated biphenyls in brain regions, blood, liver, and fat of adult rats following repeated exposure to Aroclor 1254.
Results indicate that concentrations that altered Ca2+ disposition and second messenger systems in vitro are achievable in brain in vivo following repeated exposure to Aroclor 1254. Expand
Differential effects of commercial polybrominated diphenyl ether and polychlorinated biphenyl mixtures on intracellular signaling in rat brain in vitro.
  • P. Kodavanti, T. Ward
  • Chemistry, Medicine
  • Toxicological sciences : an official journal of…
  • 1 June 2005
Results indicate that PBDEs perturbed intracellular signaling mechanisms in rat brain as do other organohalogen compounds and the efficacy between the commercial PCB and PBDE mixtures seem to vary with different endpoints. Expand
Differential effects of two lots of aroclor 1254: congener-specific analysis and neurochemical end points.
The effects seen with two lots of Aroclor 1254 in neuronal cells were not predicted based on the TCDD toxic equivalents (TEQs), although TEQs predicted the effects on ethoxyresorufin-O-deethylase (EROD) or methoxyresorbent-o-de methylase (MROD) activities. Expand
Behavioral and neurochemical changes in rats dosed repeatedly with diisopropylfluorophosphate.
Results indicate that animals showing a definitive sign of tolerance to OP administration (subsensitivity to a cholinergic agonist) were also functionally impaired on both the mnemonic and motoric demands of a working memory task. Expand
Organophosphorus compounds preferentially affect second messenger systems coupled to M2/M4 receptors in rat frontal cortex
  • T. Ward, W. Mundy
  • Chemistry, Medicine
  • Brain Research Bulletin
  • 31 December 1996
The results suggest that paraoxon, malaox on, and chlorpyrifos oxon can act as agonists at the M2 and/or M4 subset of muscarinic receptors. Expand
Correlation of the anticholinesterase activity of a series of organophosphates with their ability to compete with agonist binding to muscarinic receptors.
The interaction of eight organophosphates with muscarinic receptors was compared to their ability to inhibit AChE activity in vitro in tissue homogenates from rat hippocampus and frontal cortex, two cholinergically enriched areas of the brain and a strong correlation was found between the ability of a compound to inhibit the activity and the ability to compete with [3H]CD binding. Expand
The effect of microwave radiation (2450 MHz) on the morphology and chromosomes of lymphocytes
Effects of microwave radiation have been examined on blood lymphocytes from Chinese hamsters that were irradiated 15 minutes each day during five consecutive days by 2450-MHz (CW) energy at powerExpand
Differential effects of polychlorinated biphenyl congeners on phosphoinositide hydrolysis and protein kinase C translocation in rat cerebellar granule cells
The present experiments found that neither 2,2'-dichlorobiphenyl (DCBP), an ortho-substituted congener, nor 3,3',4,4',5-pentachlorob Pipenyl (PCBP), a non-ortho- Substituting Congener, affected basal phosphoinositide (PI) hydrolysis in cerebellar granule cells. Expand
Developmental Exposure to Polychlorinated Biphenyls Interferes with Experience-Dependent Dendritic Plasticity and Ryanodine Receptor Expression in Weanling Rats
Findings identify PCBs as candidate environmental risk factors for neurodevelopmental disorders, especially in children with heritable deficits in calcium signaling, and these effects may be linked to changes in RyR expression and function. Expand
Blood-brain barrier permeation in the rat during exposure to low-power 1.7-GHz microwave radiation.
No change in uptake of either tracer was found in any of the eight regions as compared with those of sham-exposed animals, and temperatures of rats were measured in eight of the brain regions by a thermistor probe that did not perturb the field. Expand