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Decreased myocyte tension development and calcium responsiveness in rat right ventricular pressure overload.
TLDR
The results suggest that the depressed cardiac function of end-stage myocardial hypertrophy may be due, in part, to altered contractile protein function. Expand
Cross-bridge kinetics in rat myocardium: effect of sarcomere length and calcium activation.
TLDR
It is concluded that Ca(2+) activation modulates force development in rat myocardium, at least in part, via a graded effect on cross-bridge kinetics, whereas SL effects are mediated mainly by recruitment of cross bridges. Expand
A Unique Case of Cardiac Arrest following K2 Abuse
TLDR
A case of out-of-hospital cardiac arrest temporally related to abuse of the synthetic cannabinoid street drug known as K2 is described. Expand
Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system.
TLDR
The relationship between growth hormone and biological aging is supported by studies demonstrating that growth hormone administration to old animals and humans raises plasma IGF-1 and results in increases in skeletal muscle and lean body mass, a decrease in adiposity, increased immune function, improvements in learning and memory, and increases in cardiovascular function. Expand
Influence of metabolic substrate on rat heart function and metabolism at different coronary flows.
TLDR
Hexanoate decreases myocardial efficiency compared with glucose in large part by increasing non-work-related oxygen demands, which impacts adversely on contractile strength and high-energy phosphate concentrations at low coronary flows. Expand
Enhanced Inhibition of L-type Ca2+ Current by β3-Adrenergic Stimulation in Failing Rat Heart
TLDR
In HF, β3-AR stimulation-induced inhibition of Ca2+ channel is enhanced and these effects are likely coupled with PTX-sensitive G-protein and partially mediated through a NOS-dependent pathway. Expand
The Frank-Starling mechanism is not mediated by changes in rate of cross-bridge detachment.
TLDR
The results suggest that the mechanisms that underlie the Frank-Starling relationship in cardiac muscle do not involve changes in the kinetics of the apparent detachment step in the cross-bridge cycle. Expand
The Frank-Starling mechanism is not mediated by changes in rate of cross-bridge detachment.
TLDR
The results suggest that the mechanisms that underlie the Frank-Starling relationship in cardiac muscle do not involve changes in the kinetics of the apparent detachment step in the cross-bridge cycle. Expand
Localization of Tissue Transglutaminase in Human Carotid and Coronary Artery Atherosclerosis: Implications for Plaque Stability and Progression
TLDR
The activation of transforming growth factor–beta-1 by TG might be an additional mechanism for the promotion of plaque stabilization and progression by increasing the synthesis of extracellular matrix components. Expand
Angiotensin II Type 1 Receptor Blockade Prevents Alcoholic Cardiomyopathy
TLDR
Irbesartan prevented the alcohol-induced decreases in LV and myocyte contraction, relaxation, peak [Ca2+]iT, and ICa,L. Expand
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