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Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity.
- J. Graff, B. Konicek, +24 authors E. Marcusson
- Biology, Medicine
- The Journal of clinical investigation
- 4 September 2007
Development of eIF4E-specific antisense oligonucleotides (ASOs) designed to have the necessary tissue stability and nuclease resistance required for systemic anticancer therapy are reported, providing the first in vivo evidence that cancers may be more susceptible to eif4E inhibition than normal tissues. Expand
HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric cancer cells.
Her2 interaction with CD44 up-regulates CXCR4 by inhibiting expression of miR-139, at the epigenetic level, in gastric cancer cells, indicating how HER2 signaling might promote gastric tumor progression and metastasis. Expand
Effects of the JAK2 Inhibitor, AZ960, on Pim/BAD/BCL-xL Survival Signaling in the Human JAK2 V617F Cell Line SET-2*
- J. Gozgit, G. Bebernitz, +9 authors M. Zinda
- Biology, Medicine
- Journal of Biological Chemistry
- 21 November 2008
Evidence is provided that JAK2 inhibition induces apoptosis by direct and indirect regulation of the anti-apoptotic protein BCL-xL, and a model in which JAK1 promotes cell survival by signaling through the Pim/BAD/BCL- xL pathway is suggested. Expand
EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex.
This study reveals a novel tumour-suppressive signalling pathway associated with kinase-activated EphB3 in non-small-cell lung cancer, and provides a potential therapeutic strategy by activating Eph B3 signalling, thus inhibiting tumour metastasis. Expand
α‐Synuclein promotes clathrin‐mediated NMDA receptor endocytosis and attenuates NMDA‐induced dopaminergic cell death
J. Neurochem. (2011) 119, 815–825.
miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1.
It is demonstrated that miR-214 is frequently upregulated in OS specimens, compared with noncancerous bone tissues, and its oncogenic effects are mediated chiefly through downregulation of LZTS1. Expand
Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression.
The combination of IL-2 with chloroquine increased long-term survival, decreased toxicity associated with vascular leakage, and enhanced immune cell proliferation and infiltration in the liver and spleen and provides a novel clinical strategy to enhance the efficacy of HDIL-2 immunotherapy for patients with cancer. Expand
TGF-β-induced miR-21 negatively regulates the antiproliferative activity but has no effect on EMT of TGF-β in HaCaT cells.
- T. Wang, Lilong Zhang, +6 authors Yong-ping Su
- Biology, Medicine
- The international journal of biochemistry & cell…
- 1 February 2012
The results suggest that miR-21 regulates the ability of epithelial cells to respond to TGF-β, with potential impact on epithelium homeostasis, wound-healing and tumorigenesis. Expand
Inhibition of the p38 kinase suppresses the proliferation of human ER-negative breast cancer cells.
The data suggest that p38 mediates the proliferation signal in breast cancer cells expressing mutant but not wild-type p53, and provides the foundation for future development of p38 inhibitors to target p38 for the treatment of p53 mutant and ER-negative breast cancers. Expand
Microglia as modulators of exosomal alpha-synuclein transmission
The results suggest that microglia play a crucial role in the transmission of α-syn via exosomal pathways, in additional to idea that the progression of PD may be altered by the modulation of exosome secretion and/or microglial states. Expand