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Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
TLDR
LGK974 is potent and efficacious in multiple tumor models at well-tolerated doses in vivo, including murine and rat mechanistic breast cancer models driven by MMTV–Wnt1 and a human head and neck squamous cell carcinoma model (HN30). Expand
A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice
TLDR
It is shown that the microRNA cluster miR302-367 is important for cardiomyocyte proliferation during development and is sufficient to induce cardiomeocyte proliferation in the adult and promote cardiac regeneration, and transient treatment with miR 302-367 mimics promoted cardiac regeneration in mice after myocardial infarction. Expand
Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns
TLDR
It is concluded that KLF2 maintains proper T cell migration patterns by linking T cell movement and transcriptional regulation of chemokine receptor expression patterns. Expand
ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers
TLDR
It is determined that achaete-scute homolog 1 (ASCL1), a transcription factor required for proper development of pulmonary neuroendocrine cells, is essential for the survival of a majority of lung cancers (both SCLC and NSCLC) with neuro endocrine features. Expand
Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase
TLDR
A link between Cullin5 (Cul5) E3 ubiquitin ligase and the heat shock protein 90 (Hsp90) chaperone complex is reported, which has implications in the effectiveness of Hsp90 targeted chemotherapy, which is currently undergoing clinical trials. Expand
Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production
TLDR
It is shown that targeting murine Foxf1 and Foxf2, encoding forkhead transcription factors, has pleiotropic effects on intestinal paracrine signaling, andFoxf proteins are mesenchymal factors that control epithelial proliferation and survival, and link hedgehog to Bmp and Wnt signaling. Expand
Up-regulation of gastric cancer cell invasion by Twist is accompanied by N-cadherin and fibronectin expression.
TLDR
The results suggest that Twist regulates cell motility and invasion in gastric cancer cell lines, probably through the N-cadherin and fibronectin production. Expand
Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization
TLDR
For the first time, the function of ACHE is described as a tumor growth suppressor in regulating cell proliferation, the relevant signaling pathways, and the drug sensitivity of HCC cells. Expand
Antibiotics that inhibit cell wall biosynthesis induce expression of the Bacillus subtilisσW and σM regulons
TLDR
Results suggest that the membrane‐localized RsiW anti‐ σ W factor mediates the transcriptional response to cell wall stress, consistent with the idea that one function of ECF σ factors is to coordinate antibiosis stress responses and cell envelope homeostasis. Expand
Cell-Cycle Control of Developmentally Regulated Transcription Factors Accounts for Heterogeneity in Human Pluripotent Cells
TLDR
It is shown that elevated expression of developmental regulators in G1 is a major determinant of heterogeneity in human embryonic stem cells, and cell-cycle regulation of developmentally regulated transcription factors is therefore an inherent feature of the mechanisms underpinning differentiation. Expand
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