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Vitamin D Deficiency and Risk of Cardiovascular Disease
Background— Vitamin D receptors have a broad tissue distribution that includes vascular smooth muscle, endothelium, and cardiomyocytes. A growing body of evidence suggests that vitamin D deficiency… Expand
Genome-wide association study of blood pressure and hypertension
Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report… Expand
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
BACKGROUND Vitamin D is crucial for maintenance of musculoskeletal health, and might also have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D concentrations include… Expand
Metabolite profiles and the risk of developing diabetes
Emerging technologies allow the high-throughput profiling of metabolic status from a blood specimen (metabolomics). We investigated whether metabolite profiles could predict the development of… Expand
Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study
Background—Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity and mortality, but lifetime risk for AF has not been estimated. Methods and… Expand
Temporal Relations of Atrial Fibrillation and Congestive Heart Failure and Their Joint Influence on Mortality The Framingham Heart Study
Background Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur together, but there is limited information regarding their temporal relations and the combined influence of… Expand
Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training.
MicroRNAs (miRNAs) are intracellular mediators of essential biological functions. Recently, plasma-based 'circulating' miRNAs (c-miRNAs) have been shown to control cellular processes, but the c-miRNA… Expand
Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease
Background— Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating hormone. In chronic kidney disease (CKD), circulating FGF-23 levels are markedly elevated and independently associated with… Expand
Multiple biomarkers for the prediction of first major cardiovascular events and death.
BACKGROUND Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events. METHODS We measured… Expand
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
Glucose ingestion after an overnight fast triggers an insulin‐dependent, homeostatic program that is altered in diabetes. The full spectrum of biochemical changes associated with this transition is… Expand