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7SL RNA Mediates Virion Packaging of the Antiviral Cytidine Deaminase APOBEC3G
ABSTRACT Cytidine deaminase APOBEC3G (A3G) has broad antiviral activity against diverse retroviruses and/or retrotransposons, and its antiviral functions are believed to rely on its encapsidationExpand
Tropospheric ozone climatology over Beijing: analysis of aircraft data from the MOZAIC program
Ozone (O 3 ) profiles recorded over Beijing from 1995 to 2005 by the Measurement of Ozone and Water Vapor by Airbus In-Service Aircraft (MOZAIC) program were analyzed to provide a first climatologyExpand
Biochemical and Genetic Characterizations of a Novel Human Immunodeficiency Virus Type 1 Inhibitor That Blocks gp120-CD4 Interactions
ABSTRACT BMS-378806 is a recently discovered small-molecule human immunodeficiency virus type 1 (HIV-1) attachment inhibitor with good antiviral activity and pharmacokinetic properties. Here, weExpand
Requirement for an Enzymatic Visual Cycle in Drosophila
BACKGROUND The visual cycle is an enzymatic pathway employed in the vertebrate retina to regenerate the chromophore after its release from light-activated rhodopsin. However, a visual cycle isExpand
Exploring the engine of anthropogenic iron cycles
Stocks of products in use are the pivotal engines that drive anthropogenic metal cycles: They support the lives of people by providing services to them; they are sources for future secondaryExpand
Assembly of HIV-1 Vif-Cul5 E3 ubiquitin ligase through a novel zinc-binding domain-stabilized hydrophobic interface in Vif.
APOBEC3G (A3G) and related cytidine deaminases are potent inhibitors of retroviruses. HIV-1 Vif hijacks the cellular Cul5-E3 ubiquitin ligase to degrade APOBEC3 proteins and render them ineffectiveExpand
Predicting enhancer transcription and activity from chromatin modifications
Enhancers play a pivotal role in regulating the transcription of distal genes. Although certain chromatin features, such as the histone acetyltransferase P300 and the histone modification H3K4me1,Expand
Differential Inhibition of Long Interspersed Element 1 by APOBEC3 Does Not Correlate with High-Molecular-Mass-Complex Formation or P-Body Association
ABSTRACT The human cytidine deaminase APOBEC3G (A3G) and other APOBEC3 proteins exhibit differential inhibitory activities against diverse endogenous retroelements and retroviruses, includingExpand
Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1.
Otubain 1 belongs to the ovarian tumor (OTU) domain class of cysteine protease deubiquitinating enzymes. We show here that human otubain 1 (hOtu1) is highly linkage-specific, cleaving Lys48Expand
Sole copy of Z2‐type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV‐1.
Human cytidine deaminase apolipoprotein B mRNA‐editing catalytic polypeptide‐like 3 (APOBEC3) proteins have been classified as either Z1‐or Z2‐type cytidine deaminases on the basis of phylogeneticExpand