• Publications
  • Influence
Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and Photoreceptors
Background Vascular endothelial growth factor (VEGF) is well known for its role in normal and pathologic neovascularization. However, a growing body of evidence indicates that VEGF also acts onExpand
  • 485
  • 14
  • PDF
Coordinated vascular endothelial growth factor expression and signaling during skeletal myogenic differentiation.
Angiogenesis is largely controlled by hypoxia-driven transcriptional up-regulation and secretion of vascular endothelial growth factor (VEGF) and its binding to the endothelial cell tyrosine receptorExpand
  • 104
  • 9
  • PDF
VEGF and TGF-β are required for the maintenance of the choroid plexus and ependyma
Although the role of vascular endothelial growth factor (VEGF) in developmental and pathological angiogenesis is well established, its function in the adult is less clear. Similarly, althoughExpand
  • 152
  • 8
  • PDF
TGF-β Is Required for Vascular Barrier Function, Endothelial Survival and Homeostasis of the Adult Microvasculature
Pericyte-endothelial cell (EC) interactions are critical to both vascular development and vessel stability. We have previously shown that TGF-β signaling between EC and mural cells participates inExpand
  • 145
  • 7
  • PDF
Notch and vascular smooth muscle cell phenotype.
The Notch signaling pathway is critical for cell fate determination during embryonic development, including many aspects of vascular development. An emerging paradigm suggests that the Notch geneExpand
  • 114
  • 5
  • PDF
Role of shear-stress-induced VEGF expression in endothelial cell survival
Vascular endothelial growth factor (VEGF) plays a crucial role in developmental and pathological angiogenesis. Expression of VEGF in quiescent adult tissue suggests a potential role in theExpand
  • 138
  • 4
  • PDF
Vascular endothelial growth factor is important for brown adipose tissue development and maintenance
Vascular endothelial growth factor (VEGF) is critical for angiogenesis, but also has pleiotropic effects on several nonvascular cells. Our aim was to investigate the role of VEGF in brown adiposeExpand
  • 53
  • 4
High glucose concentrations alter hypoxia-induced control of vascular smooth muscle cell growth via a HIF-1alpha-dependent pathway.
Induction of diabetes can produce arterial wall hypoxia preceding the formation of vascular lesions. We therefore determined whether a dynamic interplay exists between hyperglycemia and the majorExpand
  • 55
  • 3
TGF-β signaling is required for maintenance of retinal ganglion cell differentiation and survival
PURPOSE To determine the role of TGF-β1 in the maintenance of retinal ganglion cell line (RGC-5) differentiation and integrity. METHODS RGC-5 cells were differentiated in media conditioned by humanExpand
  • 40
  • 3
Inhibition of VEGF or TGF-β Signaling Activates Endothelium and Increases Leukocyte Rolling
Objective—Motivated by the central roles that vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-β play in the assembly and maintenance of the vasculature, we examined theExpand
  • 51
  • 2
  • PDF