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Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells.
- X. Cui, T. Wakai, Y. Shirai, N. Yokoyama, K. Hatakeyama, S. Hirano
- Medicine, Biology
- Human pathology
- 1 March 2006
In the present study, we investigated methylation status of the CpG islands of some major tumor suppressor genes both in human hepatocellular carcinoma and liver cancer cell lines and examined… Expand
Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung cancer in A/J mice.
- X. Cui, T. Wakai, Y. Shirai, K. Hatakeyama, S. Hirano
- Biology, Medicine
- Toxicological sciences : an official journal of…
- 1 June 2006
Although inorganic arsenate (iAs(V)) or arsenite (iAs(III)) is clearly a human carcinogen, it has been difficult to produce tumors in rodents. In the present study, we orally administered iAs(V) to… Expand
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
p62/Sqstm1 is a multifunctional protein involved in cell survival, growth and death, that is degraded by autophagy. Amplification of the p62/Sqstm1 gene, and aberrant accumulation and phosphorylation… Expand
High risk of gallbladder carcinoma in elderly patients with segmental adenomyomatosis of the gallbladder.
- N. Nabatame, Y. Shirai, A. Nishimura, N. Yokoyama, T. Wakai, K. Hatakeyama
- Medicine, Biology
- Journal of experimental & clinical cancer…
- 1 December 2004
The clinical significance of adenomyomatosis of the gallbladder remains unclear. This study aimed to clarify the relationship between segmental adenomyomatosis and gallbladder carcinoma, and to… Expand
Impact of ductal resection margin status on long‐term survival in patients undergoing resection for extrahepatic cholangiocarcinoma
The current study was performed to clarify whether the presence of residual carcinoma in situ at ductal resection margins differs prognostically from residual invasive ductal lesions in patients… Expand
Appraisal of 1 cm Hepatectomy Margins for Intrahepatic Micrometastases in Patients with Colorectal Carcinoma Liver Metastasis
BackgroundThis study sought to clarify the distribution of intrahepatic micrometastases and elucidate an adequate hepatectomy margin for colorectal carcinoma liver metastases.MethodsIntrahepatic… Expand
Condensin I-mediated mitotic chromosome assembly requires association with chromokinesin KIF4A.
The chromokinesin KIF4A has been implicated in shaping mitotic chromosomes, but its functional relationship to condensin complexes remains controversial. Here, we found that, in mitosis, KIF4A… Expand
Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy
- M. Nagahashi, K. Takabe, +5 authors T. Wakai
- Biology, Medicine
- BioMed research international
- 15 July 2014
Sphingosine-1-phosphate (S1P) is a pleiotropic lipid mediator that regulates cell survival, migration, the recruitment of immune cells, angiogenesis, and lymphangiogenesis, all of which are involved… Expand
Resolvins and omega three polyunsaturated fatty acids: Clinical implications in inflammatory diseases and cancer.
- Kazuki Moro, M. Nagahashi, Rajesh Ramanathan, K. Takabe, T. Wakai
- World journal of clinical cases
- 16 July 2016
Inflammation is a central process in several disorders and contributes to cancer progression. Inflammation involves a complex cascade of pro-inflammatory and anti-inflammatory signaling events with… Expand
Radical Second Resection Provides Survival Benefit for Patients with T2 Gallbladder Carcinoma First Discovered after Laparoscopic Cholecystectomy
Port site recurrence or peritoneal seeding is a fatal complication following laparoscopic cholecystectomy for gallbladder carcinoma. The aims of this retrospective analysis were to determine the… Expand