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The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.
BACKGROUND Athletes often take androgenic steroids in an attempt to increase their strength. The efficacy of these substances for this purpose is unsubstantiated, however. METHODS We randomlyExpand
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Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle.
Although testosterone levels and muscle mass decline with age, many older men have serum testosterone level in the normal range, leading to speculation about whether older men are less sensitive toExpand
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Effects of Testosterone Treatment in Older Men.
BACKGROUND Serum testosterone concentrations decrease as men age, but benefits of raising testosterone levels in older men have not been established. METHODS We assigned 790 men 65 years of age orExpand
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Effects of testosterone replacement with a nongenital, transdermal system, Androderm, in human immunodeficiency virus-infected men with low testosterone levels.
Although weight loss associated with human immunodeficiency virus (HIV) infection is multifactorial in its pathogenesis, it has been speculated that hypogonadism, a common occurrence in HIV disease,Expand
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Association of sex hormones with sexual function, vitality, and physical function of symptomatic older men with low testosterone levels at baseline in the testosterone trials.
CONTEXT The prevalence of sexual dysfunction, low vitality, and poor physical function increases with aging, as does the prevalence of low total and free testosterone (TT and FT) levels. However, theExpand
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Design of a randomized trial to determine the optimum protein intake to preserve lean body mass and to optimize response to a promyogenic anabolic agent in older men with physical functional
The dietary protein allowance for older men to maintain lean body mass and muscle strength and to accrue optimal anabolic responses to promyogenic stimuli is poorly characterized. The OPTIMEN trialExpand
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The Testosterone Trials: Seven coordinated trials of testosterone treatment in elderly men
Background The prevalence of low testosterone levels in men increases with age, as does the prevalence of decreased mobility, sexual function, self-perceived vitality, cognitive abilities, boneExpand
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Serum Neuregulin-1β as a Biomarker of Cardiovascular Fitness
PURPOSE: Neuregulins (NRG) are growth factors that bind to receptors of the erbB family, and are known to mediate a number of processes involved in diverse tissues. Neuregulin-1beta is expressed inExpand
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Effects of testosterone administration (and its 5‐alpha‐reduction) on parenchymal organ volumes in healthy young men: findings from a dose‐response trial
Animal data shows that testosterone administration increases the volume of some parenchymal organs. However, the effects of exogenous testosterone on solid abdominal organs in humans remain unknown.Expand
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A simple, accurate technique for determining work rate (watts) on the treadmill.
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