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Oxidative Stress in Schizophrenia
TLDR
There is a need for well designed, placebo controlled trials with supplementation therapy in schizophrenia, according to the meta-analysis vitamin E could potentially improve tardive dyskinesia, while for the effect of therapy with polyunsaturated fatty acids there is no clear evidence.
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The Role of Reactive Species in Epileptogenesis and Influence of Antiepileptic Drug Therapy on Oxidative Stress
TLDR
It is proposed that calcium can pose both, physiological and pathological effects of mitochondrial function, which can lead in neuronal cell death and consequent epileptic seizures, and an important role of antioxidants as having a putative antiepileptic potential is supported.
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HPLC analysis of raloxifene hydrochloride and its application to drug quality control studies.
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PLASMA MALONDIALDEHYDE, BIOCHEMICAL AND HAEMATOLOGICAL PARAMETERS IN STANDARDBRED HORSES DURING A SELECTED FIELD EXERCISE TEST
Cilj ove studije je bio da se utvrde promene u koncentraciji malonil-dialdehida (MDA) u krvnoj plazmi kao i hematoloski i biohemijski profil kod 10 klinicki zdravih americkih kasaca podvrgnutih…
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Dried blood spots for monitoring and individualization of antiepileptic drug treatment.
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Pharmacokinetics of lamotrigine and its metabolite N-2-glucuronide: Influence of polymorphism of UDP-glucuronosyltransferases and drug transporters.
TLDR
Variability in lamotrigine pharmacokinetics is large and quantification of its sources may lead to more precise individual treatment, and Genotyping for UGT2B7 may be useful in various clinical settings.
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Simultaneous determination of gabapentin, pregabalin, vigabatrin, and topiramate in plasma by HPLC with fluorescence detection.
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Oxidative stress in schizophrenia patients treated with long-acting haloperidol decanoate
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Vitamin E and essential polyunsaturated fatty acids supplementation in schizophrenia patients treated with haloperidol
TLDR
This study indicates that supplementation with vitamin E and EPUFAs may improve the antioxidative defense, especially glutathione system, while there is no major effect on symptoms severity.
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Simple and sensitive high performance liquid chromatography method with fluorescence detection for therapeutic drug monitoring of topiramate.
TLDR
A simple, sensitive, accurate, precise and inexpensive HPLC method with fluorescence detection, suitable for routine therapeutic drug monitoring (TDM) of an antiepileptic drug topiramate, was developed and validated and was applied for the measurement of plasma topIRamate concentrations in patients with epilepsy.
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