• Publications
  • Influence
The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin.
The oxazolidinones are a novel class of antibiotics that act by inhibiting protein synthesis. It as been reported that the drug exerts its primary activity on the initiation phase of translation. InExpand
  • 216
  • 8
Mechanistic roles of neutral surfactants on concurrent polarized and passive membrane transport of a model peptide in Caco-2 cells.
The transport of the model peptide Acf(NMef)2NH2 across Caco-2 cell monolayers was studied in the apical (AP) to basolateral (BL) and the BL to AP direction in the presence of Polysorbate 80 orExpand
  • 131
  • 4
Predicting Drug Absorption: How Nature Made It a Difficult Problem
Significant recent work has focused on predicting drug absorption from structure. Several misperceptions regarding the nature of absorption seem to be common. Among these is that intestinalExpand
  • 81
  • 3
  • PDF
The Madin Darby Canine Kidney (MDCK) Epithelial Cell Monolayer as a Model Cellular Transport Barrier
Two strains of Madin Darby canine kidney (MDCK) cells were grown on a polycarbonate membrane with 3-µm pores without any extracellular matrix treatment. The membrane, 2.45 cm in diameter, which isExpand
  • 161
  • 2
Influence of molecular flexibility and polar surface area metrics on oral bioavailability in the rat.
The relationship of rotatable bond count (N(rot)) and polar surface area (PSA) with oral bioavailability in rats was examined for 434 Pharmacia compounds and compared with an earlier report fromExpand
  • 132
  • 2
DNA Damage Repair Genes Controlling Human Papillomavirus (HPV) Episome Levels under Conditions of Stability and Extreme Instability
DNA damage response (DDR) genes and pathways controlling the stability of HPV episomal DNA are reported here. We set out to understand the mechanism by which a DNA-binding, N-methylpyrrole-imidazoleExpand
  • 42
  • 2
Synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid antidiabetic agent.
3-Guanidinopropionic acid (1, PNU-10483) has been demonstrated to both improve insulin sensitivity and to promote weight loss selectively from adipose tissue in animal models of non-insulin-dependentExpand
  • 57
  • 2
The integrated value of serum procollagen III peptide over time predicts hepatic hydroxyproline content and stainable collagen in a model of dietary cirrhosis in the rat
To determine whether a serum parameter of collagen metabolism, serum procollagen type III peptide, correlated with hepatic collagen in a model of diet‐induced fibrosis, rats were fed a control orExpand
  • 95
  • 1
Peptides Are Better Absorbed from the Lung than the Gut in the Rat
  • 16
  • 1
The KKAy mouse: a model for the rapid development of glomerular capillary basement membrane thickening.
The renal tissue of 12-, 29-, 90- and 165-day-old genetically obese, hyperphagic, diabetic KKAy and age-matched nondiabetic C57BL/6 mice was morphometrically analyzed to characterize the developmentExpand
  • 32
  • 1