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Effect of long term estrogen and lithium treatment on restraint induced gastric erosion in intact and ovariectomized rats.
Ovariectomy protected rats against gastric erosions and that estrogen replacement treatment did not reduce the protection afforded by ovariectomy, and it is demonstrated that estrogen-lithium administration reduces erosion and that the mechanism could be through decreasing histamine release from gastric tissue.
Lithium effects on haloperidol‐induced pre‐ and postsynaptic dopamine receptor supersensitivity †
- T. Verimer, D. Goodale, J. P. Long, J. Flynn
- Biology, PsychologyThe Journal of pharmacy and pharmacology
- 1 September 1980
Supporting evidence is produced in a behavioural model that chronic haloperidol treatment does cause presynaptic DA receptor supersensitivity and that this effect can be blocked by chronic administration of lithium.
Congeners of the beta conformer of dopamine derived from cis- and trans-octahydrobenzo[f]quinoline and trans-octahydrobenzo[g]quinoline.
R rigid congeners of the beta conformer derived from linearly and angularly annelated octahydrobenzoquinolines have been synthesized and present a clear separation of CNS effects from some potent peripheral effects.
Derivatives of 5-hydroxy-6-methyl-2-aminotetralin.
- J. Cannon, D. L. Koble, J. P. Long, T. Verimer
- Chemistry, BiologyJournal of medicinal chemistry
- 1 July 1980
Three title compounds were designed to provide semirigid congeners of m-tyramine in which the ring position ortho to the phenolic OH is blocked to metabolic hydroxylation and were potent in a cat cardioaccelerator nerve assay, which involves dopamine receptors.
Pharmacological effects of 2-aminotetralins, octahydrobenzo[f]quinolines and clonidine on the isolated guinea pig ileum.
5,7-Dihydroxy-2-aminotetralin derivatives: synthesis and assessment of dopaminergic and adrenergic actions.
The resorcinol- derived 2-aminotetralins were less potent and less active dopaminergic agents than their catechol-derived isomers, and certain of the subject compounds demonstrated alpha- and beta 1-adrenoceptor activating properties.
Dopaminergic activity of cis-trans isomers of benzhydro[f]quinoline analogs.
The effects of yohimbine and neuroleptics on apomorphine-induced pecking behaviour in the pigeon
In vitro neuromuscular effects of delta9-trans-tetrahydrocannabinol (THC).
Subsensitivity of the presynaptic dopamine receptors in cat heart after the termination of chronic haloperidol treatment.
- T. Verimer, J. P. Long, J. Flynn, S. Arneric, B. Walsh
- Biology, PsychologyArchives internationales de pharmacodynamie et de…
- 1 October 1981
The results suggest that presynaptic dopamine receptors on cat cardioaccelerator nerve terminals become subsensitive following withdrawal of chronic haloperidol treatment.