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Impact of Different Extraction Solvents on Phenolic Content and Antioxidant Potential of Pinus densiflora Bark Extract
TLDR
Examining the impact of different extraction solvents such as ethanol, methanol, isopropanol, acetonitrile, and acetone at a different percentage with water on antioxidant efficiency as well as the total phenolic content (TPC) of Pinus densiflora bark extracts concluded that an increased Phenolic content in PDB extracts proportionally increases their antioxidant efficiency.
Pinus densiflora needle supercritical fluid extract suppresses the expression of pro-inflammatory mediators iNOS, IL-6 and IL-1β, and activation of inflammatory STAT1 and STAT3 signaling proteins in
TLDR
Evaluated effects of Pinus densiflora needle supercritical fluid extract on bacterial lipopolysaccharide (LPS)-induced inflammatory response in RAW 264.7 macrophages revealed that the anti-inflammatory activity of PDN-SCFE is probably caused by the suppression of the JAK-STAT signaling pathway.
Falcarindiol inhibits LPS-induced inflammation via attenuating MAPK and JAK-STAT signaling pathways in murine macrophage RAW 264.7 cells
TLDR
Evidence is provided that FAD inhibits the production of major pro-inflammatory molecules in LPS-challenged murine macrophages via suppression of JNK, ERK, and STAT signaling pathways.
Comparative evaluation of the impact of extraction solvent and time on the yield and antioxidant potential of Pinus densiflora needle and bark extracts
This study was aimed to determine and compare the effect of different percentages of extraction solvent ethanol 0% (E0), 20% (E20), and 40% (E40) with water (vol/vol) as well as extraction time 6, 9
Pinus radiata bark extract induces caspase-independent apoptosis-like cell death in MCF-7 human breast cancer cells
TLDR
The results suggest that PRE induces an autophagic block, LMP, ER stress, and mitochondrial dysfunction in MCF-7 cells, however, further studies are clearly warranted to explore the exact mechanism behind the anticancer activity of PRE in MCf-7 human breast cancer cells.
Antidiabetic activity of gossypin, a pentahydroxyflavone glucoside, in streptozotocin‐induced experimental diabetes in rats
TLDR
The aim of the present study was to evaluate the effect of gossypin in streptozotocin (STZ)‐induced experimental diabetes in rats.
Anti-inflammatory activity of Ternstroemia gymnanthera stem bark extracts in bacterial lipopolysaccharide-stimulated RAW264.7 murine macrophage cells
TLDR
TGSBE suppresses the inflammatory response by inhibiting the NF-κB and MAPK cascades exhibiting therapeutic potential to treat inflammatory diseases associated with increased activation of macrophages.
Deoxyrhapontigenin, a Natural Stilbene Derivative Isolated From Rheum undulatum L. Induces Endoplasmic Reticulum Stress–Mediated Apoptosis in Human Breast Cancer Cells
TLDR
The present study suggests that the induction of ER stress–mediated apoptosis by DR may account for its cytotoxic effects in human breast cancer cells.
Antiviral Activities of Compounds Isolated from Pinus densiflora (Pine Tree) against the Influenza A Virus
Pinus densiflora was screened in an ongoing project to discover anti-influenza candidates from natural products. An extensive phytochemical investigation provided 26 compounds, including two new
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