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The frequency of cytochrome P450 2C9 genetic variants in the Russian population and their associations with individual sensitivity to warfarin therapy.
0049-3848/$ see front matter D 200 doi:10.1016/j.thromres.2004.08.020 Abbreviations: INR, international polymerase chain reaction; SNPs, sin phisms; DNA, deoxyribonucleic acid; S * CorrespondingExpand
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[Clinical value of allele variants of cytochrome CYP2C9 gene for anticoagulation therapy with warfarin].
Warfarin is metabolized by cytochrome CYP2C9 and its pharmacokinetic properties depend on structural polymorphisms of CYP2C9 gene. We studied frequencies of allele variants of CYP2C9 gene andExpand
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Genetic variants of platelet ADP receptor P2Y12 associated with changed platelet functional activity and development of cardiovascular diseases
The key role in platelet aggregation is played by the platelet ADP receptor P2Y12, which is the target for antiaggregant drugs, clopidogrel and ticlopidine. At present, only sporadic data on geneticExpand
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Early diagnostics of kidney damage in longstanding rheumatoid arthritis and amyloidosis
Abstract: We studied a group of patients with longstanding rheumatoid arthritis (27 patients), a group of patients with different degree of kidney insufficiency (8 patients), and 19 healthy people....
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Increase in GP IIb-IIIa and P2Y12 receptors in activated platelets as the possible indicator of de novo protein synthesis
Although platelets lack nuclei, they are capable of de novo protein synthesis. We speculate that key platelet receptors are involved in the regulation of this process, and the changes in their numberExpand
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Participation of IIb-IIIa glycoprotein in spontaneous platelet aggregation
In some patients with stable and unstable angina pectoris and in some donors without clinical manifestations of cardiovascular diseases and other pathologies, spontaneous platelet aggregation wasExpand
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[Models of inter-group difference of the homeostasis system in patients with artificial heart valves and the set of laboratory parameters].
Patients with artificial heart valves (AHV) belong to a unique multi-component model of the homeostasis system presenting an interaction of activated coagulation processes and pharmacologicalExpand
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The molecular mechanisms of platelet activation in patients with cerebrovascular disease
Cerebrovascular diseases are the second leading cause of mortality and are one of the most important medical and social problems. After the damage of the vascular wall endothelial cells secrete vonExpand
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Application of high-sensitivity flow cytometry in combination with low-voltage scanning electron microscopy for characterization of nanosized objects during platelet concentrate storage
Abstract Platelet concentrates are used in clinic for therapy and prophylaxis of conditions associated with platelet deficiency or malfunction. The characteristics of platelet concentrates graduallyExpand
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