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Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library
TLDR
This work shows that conventional hybridoma technology may be superseded by large phage libraries that are proving to be a stable and reliable source of specific, high affinity human monoclonal antibodies. Expand
Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator.
TLDR
A fully human monoclonal antibody has been isolated that binds toBLyS with high affinity and neutralizes human BLyS bioactivity in vitro and in vivo. Expand
HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo
TLDR
In vivo administration of HGS-ETR1 resulted in rapid tumour regression or repression of tumour growth in pre-established colon, non-small-cell lung, and renal tumours in xenograft models, and combined with chemotherapeutic agents resulted in an enhanced antitumour efficacy compared to either agent alone. Expand
Homologies between members of the germin gene family in hexaploid wheat and similarities between these wheat germins and certain Physarum spherulins.
TLDR
Evidence can be interpreted to suggest that the biochemistry of germins and spherulins is involved with cellular, perhaps cell-wall responses to desiccation, hydration, and osmotic stress. Expand
Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation
TLDR
This work reports that the biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by the formation of two disulphide bridges, resulting in an extensive conformational change that disrupts the ST2 binding site. Expand
A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope.
TLDR
The finding that the D5 fusion-inhibitory antibody shares the same binding site suggests that the hydrophobic pocket is a "hot spot" for fusion inhibition and an ideal target on which to focus a vaccine-elicited antibody response. Expand
Modelling the human immune response: performance of a 1011 human antibody repertoire against a broad panel of therapeutically relevant antigens.
TLDR
Analysis of a sample of >800 antibodies from the unselected library indicates V gene usage is representative of the human immune system with no strong bias towards any particular V(H)-V(L) pairing. Expand
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo
TLDR
A structural proteomics approach is described to identify the amino acids responsible for aberrant self-association of monoclonal antibodies and the design of a variant with reduced aggregation and increased serum persistence in vivo and represents a powerful and generic approach to improve the properties of therapeutic proteins. Expand
Human antibodies by design
TLDR
Mabs that are entirely human are now being produced from phage display and transgenic mice, and together with recent advances in these technologies, may finally realize the full potential of antibodies. Expand
The remarkable flexibility of the human antibody repertoire; isolation of over one thousand different antibodies to a single protein, BLyS.
TLDR
It is demonstrated that specific recognition of a single antigen can be achieved from many different VDJ combinations, illustrating the remarkable problem-solving ability of the human immune repertoire. Expand
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