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Cellular Binding of Hepatitis C Virus Envelope Glycoprotein E2 Requires Cell Surface Heparan Sulfate*
TLDR
It is demonstrated for the first time that cellular binding of HCV envelope requires E2-HSPG interaction, and docking of E2 to cellular HSPG may be the initial step in the interaction between HCV and the cell surface resulting in receptor-mediated entry and initiation of infection. Expand
Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity
TLDR
It is concluded that cancer cell-derived exosomes use heparan sulfate proteoglycans (HSPGs) for their internalization and functional activity, which significantly extends the emerging role of HSPGs as key receptors of macromolecular cargo. Expand
Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis.
TLDR
It is demonstrated that PECs contribute to the development and progression of the sclerotic lesions that define FSGS, but this pathogenesis may be relevant to all etiologies of glomerulosclerosis. Expand
Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity.
TLDR
Structural analysis and Mitogenesis assays with FGF2 revealed that Sulf activity decreases the activating potential of newly-synthesized HS, suggesting an important role for these enzymes in cell growth regulation in embryonic and adult tissues. Expand
Development of tailor-made collagen-glycosaminoglycan matrices: EDC/NHS crosslinking, and ultrastructural aspects.
TLDR
It is concluded that EDC/NHS is generally applicable for attachment of GAGs to collagen and modulation of crosslinking conditions provides matrices with well-defined GAG contents, and biodegradabilities. Expand
Induction of glomerular heparanase expression in rats with adriamycin nephropathy is regulated by reactive oxygen species and the renin-angiotensin system.
TLDR
Results suggest involvement of radicals and angiotensin II in the modulation of GBM permeability through HS and heparanase expression and the effects of DMTU suggest a role for reactive oxygen species in upregulation of heparinase. Expand
Hemoglobin and myoglobin content in muscles of broiler chickens.
TLDR
A combination of spectrophotometric analysis of the total heme protein concentration and measurement of the myoglobin concentration, applying size exclusion chromatography, proved to be a reliable and reproducible method to determine the hemoglobin and myoglobin content in chicken muscles. Expand
Preparation and characterization of porous crosslinked collagenous matrices containing bioavailable chondroitin sulphate.
TLDR
It is concluded that the use of ethanol during EDC crosslinking, offers an elegant means for the preparation of defined porous collagenous matrices containing bioavailable, covalently attached CS. Expand
Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum.
TLDR
It is concluded that the phenotype of the Abcc6-/- mouse shares calcification of elastic fibres with human PXE pathology, which makes this model a useful tool to further investigate the aetiology of PxE. Expand
Chondroitin 6‐sulphate synthesis is up‐regulated in injured CNS, induced by injury‐related cytokines and enhanced in axon‐growth inhibitory glia
TLDR
The results suggest that the up‐regulation of CSPG after CNS injury is associated with a specific sulphation pattern on CS‐GAGs, mediating the inhibitory properties of proteoglycans on axonal regeneration. Expand
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