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Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock
The role of individual receptors such as the toll-like receptors and CD14 in the induction of proinflammatory cytokines and adhesion molecules is discussed in detail and the therapies for the treatment of bacterial sepsis and septic shock are discussed in relation to the action of these receptors and proteins.
Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.
- Jayaprakash K. Nair, J. Willoughby, M. Manoharan
- Biology, ChemistryJournal of the American Chemical Society
- 1 December 2014
The optimally chemically modified siRNA-GalNAc conjugates are hepatotropic and long-acting and have the potential to treat a wide range of diseases involving liver-expressed genes.
The peripheral blood mononuclear cell microRNA signature of coronary artery disease.
The blood-brain barrier in neuroinflammatory diseases.
- H. D. de Vries, J. Kuiper, A. D. De Boer, T. V. van Berkel, D. Breimer
- BiologyPharmacological reviews
- 1 June 1997
The existence of the blood-brain barrier (BBB)bwas revealed through studies by [Ehrlich (1885)] in the late 19th century, describing that brain tissue remained unstained after injection of a vital…
Genetic variant of the scavenger receptor BI in humans.
- M. Vergeer, S. Korporaal, J. Kuivenhoven
- Medicine, BiologyThe New England journal of medicine
- 12 January 2011
Reduced SR-BI function was associated with altered platelet function and decreased adrenal steroidogenesis, and a family with a functional mutation in SR- BI was identified.
FTY720, a Synthetic Sphingosine 1 Phosphate Analogue, Inhibits Development of Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice
The present results demonstrate that an S1P analogue inhibits atherosclerosis by modulating lymphocyte and macrophage function, and these results are consistent with the notion that S 1P contributes to the antiatherogenic potential of high-density lipoprotein.
Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development.
Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2.
It is demonstrated that shear stress and KLF2 inhibit nuclear activity of ATF2, providing a potential mechanism by which endothelial cells exposed to laminar flow are protected from basal proinflammatory, atherogenic gene expression.
Induction of Rapid Atherogenesis by Perivascular Carotid Collar Placement in Apolipoprotein E–Deficient and Low-Density Lipoprotein Receptor–Deficient Mice
It is proposed that this model of collar-induced acceleration of carotid atherogenesis is of hemodynamic cause and may serve as a substrate for sequential mechanistic studies concerned with the underlying cause and pathogenesis of atherosclerosis.
Different fate in vivo of oxidatively modified low density lipoprotein and acetylated low density lipoprotein in rats. Recognition by various scavenger receptors on Kupffer and endothelial liver…