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The human dopamine D5 receptor gene: cloning and characterization of the 5'-flanking and promoter region.
Genomic and overlapping cDNA clones encompassing the entire 5'-untranslated region of the human D5 receptor gene were cloned and sequenced. Comparison of these human D5 receptor genomic and cDNA… Expand
Two gene duplication events in the human and primate dopamine D5 receptor gene family.
The human dopamine D5 receptor (DRD5) gene family consists of the DRD5-encoding gene (DRD5) and the pseudogenes psi DRD5-1 and psi DRD5-2. Analysis of the 5' UTR of DRD5 and homologous regions in the… Expand
Diazepam metabolism by rat and human liver in vitro: inhibition by mephenytoin.
- T. V. Beischlag, W. Kalow, W. A. Mahon, T. Inaba
- Chemistry, Medicine
- Xenobiotica; the fate of foreign compounds in…
1. Diazepam metabolism and its association with mephenytoin hydroxylase were studied in vitro using human and rat livers. 2. Enzyme kinetic parameters were obtained for the formation of… Expand
A polymorphic dinucleotide repeat in the human dopamine D5 receptor gene promoter
- T. V. Beischlag, D. Nam, C. Ulpian, P. Seeman, H. Niznik
- Biology, Medicine
- Neuroscience Letters
- 1 March 1996
Previously, we have reported the cloning and characterization of the 5'-flanking region of the human dopamine D5 receptor encoding gene (D5) and that the major transactivation domain was 119-182 bp… Expand
Determination of nonderivatized para-hydroxylated metabolites of diazepam in biological fluids with a GC Megabore column system.
A method was developed using gas chromatography (GC) and a Megabore column system capable of simultaneous detection of diazepam, N-desmethyldiazepam, temazepam, oxazepam, and their para-hydroxylated… Expand