• Publications
  • Influence
Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate.
TLDR
Surprisingly, nonsulfated chondroitin is indispensable in the morphogenesis and cell division of Caenorhabditis elegans, as revealed by RNA interference experiments of the recently cloned chondDetroitin synthase gene and by the analysis of mutants of squashed vulva genes.
Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis.
TLDR
A novel mechanistic pathway driven by heparanase expression in myeloma cells whereby elevated levels of VEGF and shed syndecan-1 form matrix-anchored complexes that together activate integrin and VEGf receptors on adjacent endothelial cells thereby stimulating tumor angiogenesis is revealed.
Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans
TLDR
It is reported that blocking chondroitin synthesis results in cytokinesis defects in early embryogenesis, and cell division eventually stops, resulting in early embryonic death.
Enzymological studies on the biosynthesis of N-acylethanolamines.
TLDR
Recent findings regarding mammalian enzymes that are involved or might be involved in the biosynthesis of NAEs, a class of endogenous lipid molecules generally called N-acylethanolamines, are focused on.
Metabolism of endocannabinoids and related N‐acylethanolamines: Canonical and alternative pathways
TLDR
Although their physiological significance is poorly understood, these new enzymes/pathways may serve as novel targets for the development of therapeutic drugs, for example, selective N‐acylethanolamine‐hydrolyzing acid amidase inhibitors are expected to be new anti‐inflammatory and analgesic drugs.
N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA).
TLDR
Recent progress in the studies on the enzymes involved in the biosynthesis and degradation of NAEs are discussed with special reference to NAAA, a lysosomal enzyme referred to as NAE-hydrolyzing acid amidase (NAAA) that may be a new target for the development of therapeutic drugs.
Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor.
TLDR
The results suggest that chondroitin polymerization is achieved by multiple combinations of ChSy-1, CSS3 and ChPF, and CSS3 is renamed CSS3 Ch Sy-2 (chondroit in synthase-2).
Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol.
TLDR
Rapid advances in enzymological research are outlined on the biosynthetic and degradative pathways of 2-AG, a monoacylglycerol molecule containing an esterified arachidonic acid chain at sn-2 position of the glycerol backbone.
Molecular Cloning and Expression of a Human Chondroitin Synthase*
TLDR
It is demonstrated that analogous to human heparan sulfate polymerases, the single polypeptide chondroitin synthase possesses two glycosyltransferase activities required for chain polymerization.
Molecular Cloning of a Chondroitin Polymerizing Factor That Cooperates with Chondroitin Synthase for Chondroitin Polymerization*
TLDR
It is reported here that the chondroitin polymerizing activity requires concomitant expression of a novel protein designated ChPF (ChPF) with mammalian ChSy, and results suggested that the ChPF acts as a specific activating factor for ChSy in chondDetroitin polymerization.
...
1
2
3
4
5
...