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Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice.
TLDR
Enteric neuron survival is sensitive to RET dosage, and cell death is potentially involved in the etiology of HSCR. Expand
Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression.
TLDR
It is found that introducing nonpolyalanine repeat expansion mutation of the PHOX2B into the mouse Phox2b locus recapitulates the clinical features of the CCHS associated with HSCR and NB, and demonstrates that Sox10 regulation by PHox2B is pivotal for the development and pathogenesis of the autonomic ganglia. Expand
Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system
TLDR
Using time-lapse imaging analyses of mouse ENCCs, it is shown that a population of EN CCs crosses from the midgut to the hindgut via the mesentery during a developmental time period in which these gut regions are transiently juxtaposed, and that such 'trans-mesenteric' ENccs constitute a large part of the hindGut ENS. Expand
Conditional ablation of GFRα1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype
TLDR
It is demonstrated that conditional ablation of GFRα1, the high affinity receptor for GDNF, in mice during late gestation induces rapid and widespread neuronal death in the colon, leading to colon aganglionosis reminiscent of Hirschsprung's disease and suggests that caspase-independent death can be triggered by abolition of neurotrophic signals. Expand
Neuronal Differentiation in Schwann Cell Lineage Underlies Postnatal Neurogenesis in the Enteric Nervous System
TLDR
It is shown that a subset of Schwann cell precursors (SCPs), which invades the gut alongside the extrinsic nerves, adopts a neuronal fate and differentiates into specific neuronal subtypes in the postnatal period and contributes to the ENS. Expand
Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neuritogenesis.
TLDR
An extensive set of ENS biomarkers are provided, a role for SNARE proteins in ENS development is demonstrated and additional candidate genes that could modify Hirschsprung's disease penetrance are highlighted. Expand
Identifying target genes regulated downstream of Cdx2 by microarray analysis.
TLDR
Differential expression of 23 genes involved in the Notch signaling pathway, xenobiotic metabolism, enzymes associated with tumor suppression, RNA binding protein, receptors, signal transduction, and transcription factors were confirmed by a semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis using gene-specific primers. Expand
Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen‐activated protein kinase superfamily, in the intestinal epithelial cells
TLDR
Analysis of the 5′‐flanking region of the MOK gene led to the identification of primary C dx2 responsive element, and an electrophoretic mobility shift assay indicated that Cdx2 binds to that element, indicating that MOK may be involved in growth arrest and differentiation in the intestinal epithelium. Expand
GDNF Signaling Levels Control Migration and Neuronal Differentiation of Enteric Ganglion Precursors
TLDR
It is demonstrated that glial cell line-derived neurotrophic factor (GDNF) is essential for the formation not only of the MGs, but the SMGs as well, establishing GDNF as a long-term acting neurotrophicfactor for ENS development in a mouse model. Expand
Development of the intrinsic and extrinsic innervation of the gut.
TLDR
Recent progress in understanding the developmental processes that occur after the gut is colonized by vagal ENS precursors are focused on, and an up-to-date overview of molecular mechanisms regulating the development of the intrinsic and extrinsic innervation of the GI tract is provided. Expand
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