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ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation
Expanded polyglutamine 72 repeat (polyQ72) aggregates induce endoplasmic reticulum (ER) stress-mediated cell death with caspase-12 activation and vesicular formation (autophagy). We examined thisExpand
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Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer.
Tumor cells stimulate the formation of stroma that secretes various mediators pivotal for tumor growth, including growth factors, cytokines, and proteases. However, little is known about the localExpand
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Akt Inhibits the Orphan Nuclear Receptor Nur77 and T-cell Apoptosis*
Akt is a common mediator of cell survival in a variety of circumstances. Although some candidate Akt targets have been described, the function of Akt is not fully understood, particularly because ofExpand
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Augmentation of Postnatal Neovascularization With Autologous Bone Marrow Transplantation
Background —Endothelial progenitor cells (EPCs) have been identified in adult human peripheral blood. Because circulating EPCs should originate from bone marrow (BM), we examined whether BMExpand
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Tissue factor expression in breast cancer tissues: its correlation with prognosis and plasma concentration
Tissue factor (TF), an initiator of the extrinsic coagulation cascade, is expressed in a wide range of cancer cells and plays important roles in cancer progression and metastasis. Recently, theExpand
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Urachal anomalies: ultrasonography and management.
BACKGROUND Fifty-six children with anomalies of the urachus remnant identified by ultrasound scan have been encountered in the authors' hospital over the last 4 years. METHODS Twenty of these 56Expand
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TIM‐1 Signaling Is Required for Maintenance and Induction of Regulatory B Cells
Apart from their role in humoral immunity, B cells can exhibit IL‐10‐dependent regulatory activity (Bregs). These regulatory subpopulations have been shown to inhibit inflammation and allograftExpand
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Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons
Investigations pursued during the last decade on neurodegenerative diseases have revealed a common mechanism underlying the development of such diseases: conformational disorder of certain proteinsExpand
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Membrane markers of endoplasmic reticulum preserved in autophagic vacuolar membranes isolated from leupeptin-administered rat liver.
We isolated membranes from leupeptin-induced autophagic vacuoles and compared them with lysosomal membranes purified from dextran-administered rats. In protein composition, autophagic vacuoleExpand
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Autolysosomal Membrane-associated Betaine Homocysteine Methyltransferase
We compared the membrane proteins of autolysosomes isolated from leupeptin-administered rat liver with those of lysosomes. In addition to many polypeptides common to the two membranes, theExpand
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