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Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
TLDR
Interference with this role of CTLA-4 suffices to elicit autoimmune disease in otherwise normal animals, presumably through affecting CD25+CD4+ T cell–mediated control of self-reactive T cells. Expand
Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1
TLDR
Tumor-associated dendritic cells in mouse tumors and patients with cancer had high expression of TIM-3, which suppressed innate immune responses through the recognition of nucleic acids by Toll-like receptors and cytosolic sensors via a galectin-9-independent mechanism. Expand
Osteopontin as a potential diagnostic biomarker for ovarian cancer.
TLDR
The findings provide evidence for an association between levels of a biomarker, osteopontin, and ovarian cancer and suggest that future research assessing its clinical usefulness would be worthwhile. Expand
TDAG8 Is a Proton-sensing and Psychosine-sensitive G-protein-coupled Receptor*
TLDR
T cell death-associated gene 8 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine, and its related lysosphingolipids behave as if they were antagonists against protein-s sensing receptors, including TDAG8, GPR4, and OGR1. Expand
Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.
TLDR
It is shown that NKT cells secrete OPN, which augments N KT cell activation and triggers neutrophil infiltration and activation and identifies NKT cell-derived OPN as a novel target for the treatment of inflammatory liver diseases. Expand
CD24 expression causes the acquisition of multiple cellular properties associated with tumor growth and metastasis.
TLDR
It is shown that ectopic CD24 expression can be sufficient to promote tumor metastasis in experimental animals and implicate CD24 in the regulation of multiple cell properties of direct relevance to tumor growth and metastasis. Expand
Essential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritis.
TLDR
It is demonstrated that a cryptic epitope, the SLAYGLR sequence of murine OPN, is critically involved in the pathogenesis of a murine model of RA. Expand
CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and
The expression of osteopontin (OPN), CD44 variants, and integrins has been correlated with tumorigenesis and metastasis. Here we show that these proteins cooperate to enhance cell motility. First, weExpand
Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice
TLDR
Results indicated that OPN plays a critical role in the destruction of joint cartilage in the rheumatoid arthritis model in mice via promotion of angiogenesis and induction of chondrocyte apoptosis. Expand
Osteopontin/Eta-1 upregulated in Crohn’s disease regulates the Th1 immune response
TLDR
Increased OPN expression facilitates cytokine production and is closely involved in the Th1 immune response associated with Crohn’s disease. Expand
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